A REVIEW ON THE STUDY OF BIOREDUCTIVE DRUGS

CHEN Xiaojing; JIN Yizun

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A REVIEW ON THE STUDY OF BIOREDUCTIVE DRUGS

更新时间：2023-03-30

- A REVIEW ON THE STUDY OF BIOREDUCTIVE DRUGS
- Journal of Radiation Research and Radiation Processing Vol. 21, Issue 2, Pages: 83-87(2003)
- 作者机构：
  
  1.复旦大学放射医学研究所　上海　200032
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CHEN Xiaojing, JIN Yizun. A REVIEW ON THE STUDY OF BIOREDUCTIVE DRUGS. [J]. Journal of Radiation Research and Radiation Processing 21(2):83-87(2003)
DOI：

CHEN Xiaojing, JIN Yizun. A REVIEW ON THE STUDY OF BIOREDUCTIVE DRUGS. [J]. Journal of Radiation Research and Radiation Processing 21(2):83-87(2003) DOI：

摘要

乏氧现象存在于多数实体肿瘤中。生物还原剂是一种具有肿瘤乏氧靶向性的前药，它会在还原性环境中被还原产生具有细胞毒性的代谢物。目前，生物还原剂主要有硝基杂环类、杂环氮氧类、醌类等几类。生物还原剂不仅可以作为放射增敏剂、化学增敏剂，还可以用于基因向导的酶前药治疗（GDEPT）。总之生物还原剂的研究对未来恶性肿瘤治疗有很大的意义。

Abstract

Hypoxia is a feature that exists in most solid tumors. Bio-reductive drugs are pro-drugs that can selectively target the hypoxia cells in tumors. In reductive environment, they are reductively metabolized to generate toxic species. There are 3 main classes of bio-reductive drugs: the nitro-aromatics, N-oxides and quinones. Recently, bio-reductive drugs were combined with GDEPT for the treatment of cancer, in addition to radiation and the chemotherapeutic agents. bio-reductive drugs will play a significant role in future cancer therapy.

关键词

生物还原剂乏氧还原酶基因向导的酶前药治疗硝基杂环化合物氮氧化合物醌类化合物

Keywords

Bio-reductive drugsHypoxiaReductive enzymesGene-directed enzyme pro-drug therapy (GDEPT)Nitro-aromaticsN-oxidesQuinones

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Related Author

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Related Institution

Institute of Radiation Medicine, Fudan University

Gray Cancer Institute, Oxford University

Department of Radiation Medicine, Faculty of Preventive Medicine, Fourth Military Medical University

1（苏州大学放射医学与防护学院放射生物学教研室）

2（苏州大学附属第一医院脑神经研究室）

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