A TIME-RESOLVED STUDY ON THE PHOTODYNAMIC PRIMARY PROCESS OF ADE: II. PHOTOCHEMISTRY IN BIOMOLECULAR COMPLEXES

PAN Jingxi; LIN Weizhen; HAN Zhenhui; MIAO Jinling; WANG Wenfeng; YAO Side; LIN Nianyun; ZHU Dayuan

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A TIME-RESOLVED STUDY ON THE PHOTODYNAMIC PRIMARY PROCESS OF ADE: II. PHOTOCHEMISTRY IN BIOMOLECULAR COMPLEXES

更新时间：2023-03-30

- A TIME-RESOLVED STUDY ON THE PHOTODYNAMIC PRIMARY PROCESS OF ADE: II. PHOTOCHEMISTRY IN BIOMOLECULAR COMPLEXES
- Journal of Radiation Research and Radiation Processing Vol. 21, Issue 2, Pages: 99-101(2003)
- 作者机构：
  
  1.中国科学院上海原子核研究所辐射化学开放实验室　上海　201800
  2.中国科学院上海药物研究所　上海　200031
- 作者简介：
- 基金信息：
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PAN Jingxi, LIN Weizhen, HAN Zhenhui, et al. A TIME-RESOLVED STUDY ON THE PHOTODYNAMIC PRIMARY PROCESS OF ADE: II. PHOTOCHEMISTRY IN BIOMOLECULAR COMPLEXES. [J]. Journal of Radiation Research and Radiation Processing 21(2):99-101(2003)
DOI：

PAN Jingxi, LIN Weizhen, HAN Zhenhui, et al. A TIME-RESOLVED STUDY ON THE PHOTODYNAMIC PRIMARY PROCESS OF ADE: II. PHOTOCHEMISTRY IN BIOMOLECULAR COMPLEXES. [J]. Journal of Radiation Research and Radiation Processing 21(2):99-101(2003) DOI：

摘要

利用激光光解结合稳态吸收光谱技术，对放线菌素D的模型化合物ADE与DNA和牛血清蛋白的相互作用进行了系统研究。结果发现，ADE与ssDNA、dsDNA以及BSA都能发生非共价结合，并能发生光诱导的电子转移反应。结果表明，放线菌素类化合物有可能被用作I型的光敏治疗药物，并将为这类化合物的结构改造提供一些有益的启示。

Abstract

By use of laser flash photolysis and steady state absorption techniques, a systematic study was carried out on the interaction of ADE, which is a kind of model compound of actinomycin D, with DNA and BSA. Non-covalent binding was found between ADE and ssDNA、dsDNA and BSA, and photoinduced electron transfer reaction was observed. These results indicate that actinomycines might be used as type I photodrugs in the future and will be helpful for structure modification of this kind of compound.

关键词

放线菌素D激光光解DNABSA电子转移

Keywords

Actinomycin DLaser flash photolysisDNABSAElectron transfer

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