Advances in mitochondrial DNA and its applicative research in radiation biology

LIU Qingjie; FENG Jiangbin; LU Xue

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Advances in mitochondrial DNA and its applicative research in radiation biology

更新时间：2023-03-30

- Advances in mitochondrial DNA and its applicative research in radiation biology
- Journal of Radiation Research and Radiation Processing Vol. 22, Issue 2, Pages: 65-68(2004)
- 作者机构：
  
  1.中国疾病预防控制中心辐射防护与核安全医学所　北京　100088
- 作者简介：
- 基金信息：
- DOI：
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LIU Qingjie, FENG Jiangbin, LU Xue. Advances in mitochondrial DNA and its applicative research in radiation biology. [J]. Journal of Radiation Research and Radiation Processing 22(2):65-68(2004)
DOI：

LIU Qingjie, FENG Jiangbin, LU Xue. Advances in mitochondrial DNA and its applicative research in radiation biology. [J]. Journal of Radiation Research and Radiation Processing 22(2):65-68(2004) DOI：

摘要

线粒体DNA是人类细胞中唯一核外遗传物质，缺乏组蛋白的保护和DNA修复系统，对辐射等氧化损伤更敏感。综述了近年来线粒体DNA与辐射敏感性、辐射剂量效应关系、辐射致突变以及肿瘤等领域的探索性研究，并就线粒体DNA研究技术在辐射生物学领域的应用前景进行阐述。

Abstract

Mitochondrial DNA (mtDNA) is the only genome outside cell nucleus. It is very sensitive to oxidative damages, such as radiation, because of absence of histone protection and lacking efficient DNA repair mechanism. The paper summarizes research progresses on mtDNA in the field of radiosensitivity, radiation dose-effect relationship, radiation-induced mutation and carcinogenesis in recent years. Prospective application of mtDNA in radiation biology is also outlined.

关键词

线粒体DNA辐射生物学应用

Keywords

Mitochondrial DNARadiation biologyApplication

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