Human dosimetry estimation of 13N-NH3·H2O based on mice biodistribution data

TANG Ganghua; WANG Mingfang; TANG Xiaolan; WU Hubing; HUANG Zuhan

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Human dosimetry estimation of ¹³N-NH₃·H₂O based on mice biodistribution data

更新时间：2023-03-30

- Human dosimetry estimation of ¹³N-NH₃·H₂O based on mice biodistribution data
- Journal of Radiation Research and Radiation Processing Vol. 22, Issue 2, Pages: 97-100(2004)
- 作者机构：
  
  1.第一军医大学南方医院南方PET中心　广州　510515
  2.华南农业大学理学院　广州　510642
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TANG Ganghua, WANG Mingfang, TANG Xiaolan, et al. Human dosimetry estimation of ¹³N-NH₃·H₂O based on mice biodistribution data. [J]. Journal of Radiation Research and Radiation Processing 22(2):97-100(2004)
DOI：

TANG Ganghua, WANG Mingfang, TANG Xiaolan, et al. Human dosimetry estimation of ¹³N-NH₃·H₂O based on mice biodistribution data. [J]. Journal of Radiation Research and Radiation Processing 22(2):97-100(2004) DOI：

摘要

由小鼠体内分布资料估算,13,N-氨水（,13,N-NH,3,•H,2,O）在人体内辐射吸收剂量，并评价其安全性。由小鼠尾静脉注射,13,N-NH,3,•H,2,O 后，在0、0.5、1、2、5、10、20、30 min 时刻处死动物，测定小鼠体内各脏器放射性分布，换算至标准人体内分布数据，按MIRD法计算人体内,13,N-NH,3,•H,2,O 辐射吸收剂量。经估算，人体肝内照射吸收剂量最高，其值为3.6×10,-3, mGy/MBq，全身内照射吸收剂量最低，约为1.7×10,-3, mGy/MBq，其他脏器内照射吸收剂量在（2.4—3.3）×10,-3, mGy/MBq之间，有效剂量为1.8×10,-3, mSv/MBq。由小鼠体内分布资料可估算人体内,13,N-NH,3,•H,2,O 吸收剂量，这些资料为临床安全应用,13,N-NH,3,•H,2,O提供了依据。

Abstract

Based on mice biodistribution data, absorbed doses in humans due to intravenous administration of ,13,N-NH,3,•H,2,O can be estimated, so as to evaluate the safety of PET diagnosis with ,13,N-NH,3,•H,2,O in humans. ,13,N-NH,3,•H,2,O was injected into mice through a tail vein. At 0, 0.5, 1, 2, 5, 10, 20 and 30 min after the injection, the mice were killed by cervical fracture and biodistribution in mice was determined. Radiation dosimetry in humans was calculated on the base of organ distribution in mice and the standard MIRD method using radioactivity-time curves for humans. The liver in humans received the highest dose of 3.6×10,-3, mGy/MBq. The whole body received the lowest dose of 1.7×10,-3, mGy/MBq, and other organs received doses between 2.4 ×10,-3, and 3.3 ×10,-3, mGy/MBq. The effective dose was estimated to be 1.8×10,-3, mSv/MBq. These results were comparable to values of absorbed doses reported by other authors on radiation dosimetry of this radiopharmaceutacal. Human radiation dosimetry can be performed by the mice biodistribution data and important data for clinical safe trial of ,13,N-NH,3,•H,2,O are provided.

关键词

13N-NH3•H2O小鼠体内生物分布辐射吸收剂量

Keywords

13N-NH3•H2OMiceIn vivo biodistributionRadiation absorbed doses

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