Comparison on sensitivity of chromosome aberrations induced by ionizing radiation between newborns and adults

DU Weixia; FU Yinghua; LEI Shujie; LU Xue

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Comparison on sensitivity of chromosome aberrations induced by ionizing radiation between newborns and adults

更新时间：2023-03-30

- Comparison on sensitivity of chromosome aberrations induced by ionizing radiation between newborns and adults
- Journal of Radiation Research and Radiation Processing Vol. 22, Issue 3, Pages: 185-188(2004)
- 作者机构：
  
  1.中国疾病预防控制中心辐射防护与核安全医学所　北京　100088
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- 基金信息：
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DU Weixia, FU Yinghua, LEI Shujie, et al. Comparison on sensitivity of chromosome aberrations induced by ionizing radiation between newborns and adults. [J]. Journal of Radiation Research and Radiation Processing 22(3):185-188(2004)
DOI：

DU Weixia, FU Yinghua, LEI Shujie, et al. Comparison on sensitivity of chromosome aberrations induced by ionizing radiation between newborns and adults. [J]. Journal of Radiation Research and Radiation Processing 22(3):185-188(2004) DOI：

摘要

探讨了电离辐射诱发T淋巴细胞染色体畸变在新生儿与成年人之间的差异。采用在完全相同条件下用,60,Co γ射线一次照射离体的新生儿脐带血和成年人静脉血，新生儿照射0.5、1.0、2.0、3.0、4.0、5.0Gy；成年人照射2.0Gy和3.0Gy，常规法分析染色体畸变率。结果表明，,60,Co γ射线照射2.0Gy和3.0Gy诱发新生儿T淋巴细胞染色体着丝粒畸变率相当于成年人的130%左右，无着丝粒畸变率两者几乎相同。,60,Co γ射线诱发新生儿T淋巴细胞染色体着丝粒畸变率符合线性2次多项式,y,=4.8104,D,2,+5.8314,D,+0.0034模式，,r,=0.9982。初步结果表明，新生儿T淋巴细胞对电离辐射的敏感性显著高于成年人。

Abstract

To compare the sensitivity of chromosome aberrations induced by ionizing radiation between newborns and adults, Cord bloods from newborns and peripheral blood from adults were exposed to ,60,Co γ−rays under same condition, and then the chromosome aberrations were analyzed by using conventional method. Results: Dicentric frequency in lymphocytes of newborns induced with 2.0Gy and 3.0Gy is about 130% more than those of adults. And the frequencies of acentric aberrations between newborns and adults are almost same; The frequencies of dicentric in lymphocytes from newborns induced by ,60,Co γ−rays fits linear-quadratic dose-response equation which is described by the formula,y,=4.8104,D,2,+5.8314,D,+0.0034 (,r,=0.9982). Sensitivity of newborn to ionizing radiation is significantly higher than that of adult.

关键词

辐射敏感性染色体畸变新生儿成年人淋巴细胞

Keywords

Radiation SensitivityChromosome aberrationsNewbornsAdultsLymphocytes

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