The studies of effect on tumor cell apoptosis of SOD and its anti−oxidation effect Ⅳ.The protection effects of SOD on oxidized damage of normal tissue with tumor−bearing mice with SOD

LIU Yongbiao; LIU Ying; ZHAO Jie; HAO Xingzhi; WANG Xu; YAO Side

您当前的位置：

首页 >

文章列表页 >

The studies of effect on tumor cell apoptosis of SOD and its anti−oxidation effect Ⅳ.The protection effects of SOD on oxidized damage of normal tissue with tumor−bearing mice with SOD

更新时间：2023-03-30

- The studies of effect on tumor cell apoptosis of SOD and its anti−oxidation effect Ⅳ.The protection effects of SOD on oxidized damage of normal tissue with tumor−bearing mice with SOD
- Journal of Radiation Research and Radiation Processing Vol. 22, Issue 5, Pages: 297-302(2004)
- 作者机构：
  
  1.中国科学院上海应用物理研究所　上海　201800
  2.徐州医学院肿瘤研究所　徐州　221002
- 作者简介：
- 基金信息：
- DOI：
  CLC：
扫描看全文
LIU Yongbiao, LIU Ying, ZHAO Jie, et al. The studies of effect on tumor cell apoptosis of SOD and its anti−oxidation effect Ⅳ.The protection effects of SOD on oxidized damage of normal tissue with tumor−bearing mice with SOD. [J]. Journal of Radiation Research and Radiation Processing 22(5):297-302(2004)
DOI：

LIU Yongbiao, LIU Ying, ZHAO Jie, et al. The studies of effect on tumor cell apoptosis of SOD and its anti−oxidation effect Ⅳ.The protection effects of SOD on oxidized damage of normal tissue with tumor−bearing mice with SOD. [J]. Journal of Radiation Research and Radiation Processing 22(5):297-302(2004) DOI：

摘要

探讨超氧化物歧化酶（SOD）对电离辐射和肿瘤化疗药物对荷瘤机体正常组织损伤的保护效应及机制，测定荷瘤鼠肝脏、脾脏、肾脏、心脏、肺、脑和骨髓组织的活性氧（ROS）、氧化产物丙二醛(MDA)水平和谷胱苷肽过氧化物酶（GSH−Px）、过氧化氢酶（CAT）活性，并观察SOD对荷瘤小鼠肝脏超微结构的影响。结果表明，荷瘤小鼠受照射和化疗药物后其骨髓、肝脏、肾脏、脾脏、组织匀浆中ROS、MDA含量明显升高，而GSH−Px和 CAT活性明显降低，其机制是电离辐射和化疗药物造成抗氧化酶的损伤及机体内ROS含量上升。加入SOD与对照组相比，显著降低荷瘤小鼠骨髓、肝脏、脾脏组织匀浆中ROS、MDA含量，略微升高 GSH−Px和 CAT活性，而对肾脏组织匀浆中ROS、MDA含量和GSH−Px和 CAT活性无明显影响，同时SOD可明显减轻电离辐射对荷瘤小鼠肝细胞超微结构破坏，SOD通过直接清除自由基和保护抗氧化酶的损伤起辐射保护作用。

Abstract

In order to investigate protection effects of SOD on the oxidized damage of normal tissues induced in chemotherapeutic drug and irradiated tumor−bearing mice, the contents of ROS and MDA, the activation of GSH−Px and CAT in liver, kidney, spleen and bone marrow have been determined. The effect of SOD on the ultra−structure of liver cell has been evaluated. It has been found that chemotherapeutic drug and irradiation can increase the contents of ROS and MDA and decrease activation of GSH−Px and CAT. And SOD can decrease contents of ROS and MDA and increase the activation of GSH−Px and CAT slightly for liver, spleen, marrow, but for kidney there is no significant change while SOD can reduce the damage of ultra−structure of liver. It can be inferred that SOD have some protection effects on the normal tissue of tumor−bearing mice via scavenging free radicals and activate anti−oxidative enzymes after TBI and drugs injection.

关键词

超氧化物歧化酶电离辐射抗肿瘤药物荷瘤小鼠活性氧丙二醛胱苷肽过氧化物酶过氧化氢酶

Keywords

Superoxide dismutaseIonizing radiationAntitumor drugsTumor−bearing miceReactive oxygen speciesMalondialdehydeGlutathione peroxidaesCatalase

references

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Meta-analysis of effects of ionizing radiation on antioxidant enzyme and malondialdehyde levels of occupational population

The changes of gelsolin in irradiated cells and its effects on oxidative injury of mice

The effects of ⁶⁰Co γ-rays irradiation on the activity of SOD and content of MDA in AT cells

The studies of effect on tumor cell apoptosis with SOD and its anti−oxidation effect III. The effect of SOD on lipid peroxidation of tumor cell of tumor−bearing mice under fractional irradiation

Studies on tumor cell apoptosis with SOD and its anti-oxidation effect II. Radio−protective effect on spleen lymphocyte of tumor−bearing mice with SOD

Related Author

No data

Related Institution

School of Public Health, University of South China

Department of Radiation Medicine, Faculty of Naval Medicine, Second Military Medicine University

School of Radiation Medicine and Public Health, Soochow University

The Radiation Oncology Department, Ningbo No.2 hospital

GSF - National Research Center Institute of Radiobiology

⁰