The effect of fullerols under UV on cell

LI Yuguo; NI Jin; HAN Ling; ZHAO Qunfen; GAO Fu; LI Qingnuan; XU Jingying; LI Wenxin

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The effect of fullerols under UV on cell

更新时间：2023-03-30

- The effect of fullerols under UV on cell
- Journal of Radiation Research and Radiation Processing Vol. 22, Issue 6, Pages: 356-360(2004)
- 作者机构：
  
  1.中国科学院上海应用物理研究所纳米生物医药研究室　上海　201800
  2.第二军医大学放射医学教研室　上海　200438
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LI Yuguo, NI Jin, HAN Ling, et al. The effect of fullerols under UV on cell. [J]. Journal of Radiation Research and Radiation Processing 22(6):356-360(2004)
DOI：

LI Yuguo, NI Jin, HAN Ling, et al. The effect of fullerols under UV on cell. [J]. Journal of Radiation Research and Radiation Processing 22(6):356-360(2004) DOI：

摘要

为了解紫外辐射下富勒烯衍生物富勒醇对细胞的生物效应，利用四唑盐比色实验（MTT）法研究了富勒醇对紫外辐照细胞的存活率影响，紫外辐照细胞时富勒醇对细胞超氧化物岐化酶（SOD）和氧化产物丙二醛（MDA）的影响，同时比较了C,60,−PVP对紫外辐照细胞的辐射生物效应。结果表明，富勒醇能够有效的防护紫外辐射对细胞造成的损伤，其机理可能是富勒醇能够吸收紫外辐照产生的自由基，使细胞膜不被紫外辐照损伤。

Abstract

The UV radioprotcetive effect of fullerols, which was compared with the effect of C,60,-PVP, was studied using cultured L02 cells. The cell survivals were determined by MTT method, SOD and MDA also were studied with chemistric colorimetry. The results showed that fullerols can effectively protect cells from damage induced by UV irradiation. The mechanism could be assosiated with the ability of fullerols to behave as an antioxidant compound, then fullerols protected cell membrane from damage by UV radiation.

关键词

富勒烯紫外辐照辐射保护

Keywords

FullereneUltraviolet radiationRadioprotective.

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Related Institution

Department of Radiation Medicine, Second Military Medical University

Shanghai Institute of Applied Physics, Chinese Academy of Sciences

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