Progresses in studies on radioresistance and its reversion of glioma

WEN Xiaoqian; LIU Fenju

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Progresses in studies on radioresistance and its reversion of glioma

更新时间：2023-03-30

- Progresses in studies on radioresistance and its reversion of glioma
- Journal of Radiation Research and Radiation Processing Vol. 23, Issue 1, Pages: 1-5(2005)
- 作者机构：
  
  1.苏州大学放射医学与公共卫生学院放射生物教研室　苏州　215007
- 作者简介：
- 基金信息：
- DOI：
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WEN Xiaoqian, LIU Fenju. Progresses in studies on radioresistance and its reversion of glioma. [J]. Journal of Radiation Research and Radiation Processing 23(1):1-5(2005)
DOI：

WEN Xiaoqian, LIU Fenju. Progresses in studies on radioresistance and its reversion of glioma. [J]. Journal of Radiation Research and Radiation Processing 23(1):1-5(2005) DOI：

摘要

胶质瘤是最常见的脑肿瘤，也是辐射抗性较强的肿瘤组织。近年来，对电离辐射诱导细胞凋亡分子机制的重视，探讨胶质瘤细胞的辐射抗性机制，寻找可逆转抗性基因，提高对肿瘤细胞的辐射敏感性，从而提高治疗的效果。本工作就胶质瘤细胞辐射抗性相关的基因、相关的酶、细胞外环境的作用及辐射抗性逆转的几个问题展开了讨论。

Abstract

Glioma is the most common neoplasm in brain, which is commonly considered as the tumor tissues with high radioresistance. There have been enhanced research activities in recent years to explore molecular mechanisms of apoptosis induced by ionization radiations, and many researchers have focused their efforts on the radioresistance mechanisms of glioma cells, in an attempt to look for the resistance genes, which could be reverted, to imporve radiosensitivity of tumor cells and the therapeutic efficacy. The paper gives a review on progresses of the studies on the gene and enzyme related to the radioresistance of glioma, and the external environment and other issues about reversion of the radioresistance.

关键词

胶质瘤放射治疗辐射抗性逆转基因

Keywords

GliomaRadiotherapyRadioresistanceReversion gene

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Jiangsu Shengze Hospital of Nanjing Medical University

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