Changes of cell cycle progression of tumor cells irradiated by <sup>60</sup>Co γ-rays

XIA Jingguang; LI Wenjian; WEI Wei; ZHAO Jing; JIN Xiaodong

您当前的位置：

首页 >

文章列表页 >

Changes of cell cycle progression of tumor cells irradiated by ⁶⁰Co γ-rays

Radiation Bio-medicine | 更新时间：2023-03-30

- Changes of cell cycle progression of tumor cells irradiated by ⁶⁰Co γ-rays
- Journal of Radiation Research and Radiation Processing Vol. 23, Issue 2, Pages: 91(2005)
- 作者机构：
  
  1.中国科学院近代物理研究所　兰州　730000
  2.中国科学院研究生院　北京　100039
- 作者简介：
- 基金信息：
- DOI：
  CLC：
扫描看全文
XIA Jingguang, LI Wenjian, WEI Wei, et al. Changes of cell cycle progression of tumor cells irradiated by ⁶⁰Co γ-rays. [J]. Journal of Radiation Research and Radiation Processing 23(2):91(2005)
DOI：

XIA Jingguang, LI Wenjian, WEI Wei, et al. Changes of cell cycle progression of tumor cells irradiated by ⁶⁰Co γ-rays. [J]. Journal of Radiation Research and Radiation Processing 23(2):91(2005) DOI：

摘要

实验测定了人肝癌细胞系SMMC-7721和hepG2、人卵巢癌细胞系HO-8910和人宫颈癌细胞系Hela受γ射线辐照后的细胞周期阻滞情况，分析了肿瘤细胞DNA损伤后的细胞周期延迟规律和检查点激活的差异。采用,60,Co γ射线，剂量率0.30Gy/min，照射剂量3Gy。在照后不同时间收集细胞，用美国贝克曼库尔特公司的流式细胞仪(Coulter® Epics XL™)测定细胞周期。实验结果如下：

Abstract

Human tumor cell lines of SMMC-7721 (liver cancer), hepG2 (liver cancer), HO-8910 (ovary cancer), and Hela (cervix cancer) were irradiated to 3Gy by ,60,Co γ rays and different cell cycle responses were found. The results showed that the SMMC-7721, hepG2 and HO-8910 cells displayed G,2,/M phase arrest and S phase temporally delayed after the irradiation. The Hela cells had an increased number of cells in both G,2,/M and S phase, which indicated that the G,2,/M and S checkpoints were both activated.

关键词

肿瘤细胞细胞周期阻滞60Co γ 射线照射

Keywords

Tumor cellsCell cycle arrest60Co γ-ray irradiation

references

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Comparison study on X-ray radiosensitivity in three tumor cell lines

Relationship between α / β and radiosensitivity and biologic effect of fractional irradiation of tumor cells

Effects of low priming dose irradiation on cell cycle arrest of HepG2 cells caused by high dose irradiation

DOSE—RATE EFFECTS ON THE INDUCTION OF DNA DOUBLE—STRAND BREAKS WITH HEAVY—ION IRRADIATION

MEK特异性抑制剂U0126对A549细胞的放射增敏作用及机制研究

Related Author

No data

Related Institution

Medical College of Northwest Minzu University

Institute of Modern Physics, the Chinese Academy of Sciences

School of Life Science, Lanzhou University

Biology Department of Lanzhou University

1 (School of Radiological Medicine and Protection of Soochow University,,)

⁰

Changes of cell cycle progression of tumor cells irradiated by 60Co γ-rays

DOI：

摘要

Abstract

关键词

Keywords

references

Changes of cell cycle progression of tumor cells irradiated by ⁶⁰Co γ-rays