Superhigh dose effects of 6 MeV EB irradiation on Ca<sup>2+</sup> and Mg<sup>2+</sup> contents in rat brain

TU Yu; ZHOU Juying; WANG Lili

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Superhigh dose effects of 6 MeV EB irradiation on Ca²⁺ and Mg²⁺ contents in rat brain

更新时间：2023-03-30

- Superhigh dose effects of 6 MeV EB irradiation on Ca²⁺ and Mg²⁺ contents in rat brain
- Journal of Radiation Research and Radiation Processing Vol. 23, Issue 3, Pages: 185-188(2005)
- 作者机构：
  
  1.苏州大学放射医学与公共卫生学院　苏州　215007
  2.苏州大学附属第一医院肿瘤放疗科　苏州　215006
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TU Yu, ZHOU Juying, WANG Lili. Superhigh dose effects of 6 MeV EB irradiation on Ca²⁺ and Mg²⁺ contents in rat brain. [J]. Journal of Radiation Research and Radiation Processing 23(3):185-188(2005)
DOI：

TU Yu, ZHOU Juying, WANG Lili. Superhigh dose effects of 6 MeV EB irradiation on Ca²⁺ and Mg²⁺ contents in rat brain. [J]. Journal of Radiation Research and Radiation Processing 23(3):185-188(2005) DOI：

摘要

观察超大剂量6MeV电子束照射对大鼠脑Ca,2+,、Mg,2+,含量的动态变化，探讨其在放射性脑损伤发病机制中的作用。对SD大鼠用6MeV电子线进行10Gy、20Gy和30Gy全脑单次照射，应用等离子直读光谱仪定量分析大鼠脑放射性损伤后不同时间、不同剂量脑组织中Ca,2+,、Mg,2+,含量的动态变化，用干－湿重法测定脑组织含水量。大鼠全脑受照射后，均存在脑组织中Ca,2+,含量升高、Mg,2+,含量下降和脑水肿的发生。其中20Gy照射后24h脑组织中Ca,2+,含量与对照组相比有显著升高（,p,<,0.05）， Mg,2+,含量在照后7天与对照组相比有显著下降（,p,<,0.05）。在照后7天，上述各指标变化的幅度为30Gy组,>,20Gy组,>,10Gy组。基于大鼠放射性脑损伤后脑组织中Ca,2+,、Mg,2+, 含量发生的变化，探讨了电离辐射所致脑损伤的机理。

Abstract

The work is to study possible mechanisms of radiation injuries to brain by observing Ca,2+, and Mg,2+, contents in electron beam irradiated rat brain. Sprague-Dawley rats were irradiated with a single dose of 10Gy, 20Gy or 30Gy by 6MeV electrons. On different days after the irradiation, Ca,2+, and Mg,2+, contents in whole brain of the rats were measured by direct-reading plasma spectrography, and the brain water content was calculated with wet-dry weight formula. In comparison to the control groups, the total tissue water and Ca,2+, content in brain of all the irradiated rats increased, while the Mg,2+, content in brain decreased. The of Ca,2+, content increased markedly (,p,<,0.05) 24h after the irradiation, and the Mg,2+, content decreased significantly (,p,<,0.05) 7d after the irradiation. The content changes became severe with increasing dose. Discusions are made on mechanisms of radiation induced brain injuries based on observations of the Ca,2+, and Mg,2+, contents changes in the rat brain.

关键词

放射性脑损伤Ca2+Mg2+大鼠

Keywords

Radiation-induced brain InjuriesCalciumMagnesiumRat

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Second Affiliated Hospital, Suzhou University

Department of Radiation Medicine, Faculty of Military Prevention Medicine,Fourth Military Medical University

Electron Microscopic Center, Faculty of Preclinical Medicine,Fourth Military Medical University

Department of Radiation Medicine, Faculty of Preventive Medicine, Fourth Military Medical University

Center of Electron Microscopy, Fourth Military Medical University

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Superhigh dose effects of 6 MeV EB irradiation on Ca2+ and Mg2+ contents in rat brain

DOI：

摘要

Abstract

关键词

Keywords

references

Superhigh dose effects of 6 MeV EB irradiation on Ca²⁺ and Mg²⁺ contents in rat brain