Computational simulation of chromosome breaks in human liver

YANG Jianshe; LI Wenjian; JING Xigang; JIN Xiaodong; WEI Wei; GUO Chuanling; GAO Qingxiang

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Computational simulation of chromosome breaks in human liver

更新时间：2023-03-30

- Computational simulation of chromosome breaks in human liver
- Journal of Radiation Research and Radiation Processing Vol. 24, Issue 1, Pages: 39-42(2006)
- 作者机构：
  
  1.　(中国科学院近代物理研究所　兰州730000
  2.中国科学院研究生院　北京100039
  3.兰州大学生命科学学院　兰州730000
- 作者简介：
- 基金信息：
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YANG Jianshe, LI Wenjian, JING Xigang, et al. Computational simulation of chromosome breaks in human liver. [J]. Journal of Radiation Research and Radiation Processing 24(1):39-42(2006)
DOI：

YANG Jianshe, LI Wenjian, JING Xigang, et al. Computational simulation of chromosome breaks in human liver. [J]. Journal of Radiation Research and Radiation Processing 24(1):39-42(2006) DOI：

摘要

建立了一种简捷的方法来计算细胞接受重离子照射后发生染色体断裂的产额。L02细胞接受碳离子照射后染色体断裂的产额，并应用早熟染色体凝集技术获得该细胞在经重离子照射后的染色体断裂产额的实验值。通过理论计算，得到了,12,C,6+,照射人正常肝细胞L02后不同吸收剂量点的染色体断裂产额，与应用早熟染色体凝集技术实验中实际获得的染色体断裂产额基本吻合。说明，细胞在接受重离子束照射的初始阶段可能是物质相互作用的物理过程，细胞内的生物机能对这一过程的干预尚未启动。提示重离子的高相对生物学效应与重离子的物理特性密切相关。

Abstract

An easy method was established for computing chromosome breaks in cells exposed to heavily charged particles. The cell chromosome break value by ,12,C,+6, ions was theoretically calculated, and was tested with experimental data of chromosome breaks by using a premature chromosome condensation technique. The theoretical chromosome break value agreed well with the experimental data. The higher relative biological effectiveness of the heavy ions was clusely correlated to its physical characteristics. In addition, the chromosome break value can be predicted off line.

关键词

重离子细胞染色体断裂计算模拟

Keywords

Carbon ionCellChromosome breakComputeSimulation

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