Spleen cell cycle changes of mice irradiated at head by 80MeV/u <sup>12</sup>C<sup>+6</sup> ions

BING Tao; DANG Bingrong; XIE Yi; QIU Rong; LI Wenjian; GUO Hongyun; LI Xueping; GAO Qingxiang; HAO Jifang; WANG Jufang; ZHANG Hong

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Spleen cell cycle changes of mice irradiated at head by 80MeV/u ¹²C⁺⁶ ions

更新时间：2023-03-30

- Spleen cell cycle changes of mice irradiated at head by 80MeV/u ¹²C⁺⁶ ions
- Journal of Radiation Research and Radiation Processing Vol. 24, Issue 1, Pages: 61-64(2006)
- 作者机构：
  
  1.中国科学院近代物理研究所　兰州　730000
  2.甘肃省医学科学院　兰州　730050
  3.兰州大学生命科学院　兰州　730000
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BING Tao, DANG Bingrong, XIE Yi, et al. Spleen cell cycle changes of mice irradiated at head by 80MeV/u ¹²C⁺⁶ ions. [J]. Journal of Radiation Research and Radiation Processing 24(1):61-64(2006)
DOI：

BING Tao, DANG Bingrong, XIE Yi, et al. Spleen cell cycle changes of mice irradiated at head by 80MeV/u ¹²C⁺⁶ ions. [J]. Journal of Radiation Research and Radiation Processing 24(1):61-64(2006) DOI：

摘要

研究重离子辐照小鼠头部对脾脏细胞周期分布的影响，为重离子放射治疗癌症和太空防护提供基础数据。80MeV/u能量的, 12,C,6+,对BALB/c小鼠头部给以0、0.5、1、2、4、10Gy的照射，用流式细胞仪测脾脏细胞周期分布。重离子辐照后36h，小鼠脾脏细胞S期细胞随着辐照剂量的增加显著减少（,p,<,0.05）； 0.5Gy组、4Gy组和10Gy组出现G,1,/G,0, 期阻滞明显阻滞（,p,<,0.05），1Gy组和2Gy组无显著变化（,p,﹥0.05）；0.5Gy组G,2,/M期细胞显著减少（,p,<,0.01），其它剂量组明显阻滞（,p,<,0.05）。重离子辐照小鼠头部对小鼠脾脏细胞周期分布有明显影响。

Abstract

After whole head irradiation (WHI) of mice with ,12,C,6+, ions (80MeV/u), changes of cycle distribution of spleen cells were studied, in an attempt to provide basic data for heavy ion radiotherapy and space radiation protection. The heads of the BALB/c mice were irradiated with 0, 0.5, 1, 2, 4 or 10Gy by the ,12,C,6+, ions. The cell cycle distribution was analyzed by flow cytometry. Thirty-six hours after the irradiation, the S phase cells were reduced significantly (,p,<,0.05) with increasing doses. The 0.5Gy, 4Gy and 10Gy WHI groups showed evident arrest in G,1,/G,0, phase (,p,<,0.05), but the 1Gy and 2Gy WHI groups had no significant arrest (,p,>,0.05). G,2,/M phase of the 0.5Gy WHI group was reduced markedly (,p,<,0.01), while the other groups showed obvious arrest (,p,<,0.05). After WHI of mice with the heavy ions, spleen cell cycle distribution of mice changed significantly.

关键词

神经内分泌系统重离子辐照脾脏细胞周期分布

Keywords

Neuro−endocrine SystemHeavy ion irradiationSpleenCell cycle distribution

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Department of Radiotherapy, The Hospital of Joint Logistic Support Force of PLA

Faculty of Naval Medicine, Naval Military Medical University

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Spleen cell cycle changes of mice irradiated at head by 80MeV/u 12C+6 ions

DOI：

摘要

Abstract

关键词

Keywords

references

Spleen cell cycle changes of mice irradiated at head by 80MeV/u ¹²C⁺⁶ ions