EFFECT OF IONIZING RADIATION ON APOPTOSIS IN MOUSE PEYER'S PATCHES

LIU Jiamei; CHEN Dong; LIU Shuzheng

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EFFECT OF IONIZING RADIATION ON APOPTOSIS IN MOUSE PEYER'S PATCHES

更新时间：2023-04-07

- EFFECT OF IONIZING RADIATION ON APOPTOSIS IN MOUSE PEYER'S PATCHES
- Journal of Radiation Research and Radiation Processing Vol. 17, Issue 2, Pages: 93-96(1999)
- 作者机构：
  
  1.白求恩医科大学组胚教研室　长春　130021
  (1).白求恩医科大学卫生部放射生物学重点实验室　长春　130021
- 作者简介：
- 基金信息：
  
  Scientific Research Foundation for Returned Overseas Chinese Scholars, State Education Commission;the National Natural Science Foundation of China(39570188)
- DOI：
  CLC：
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LIU Jiamei, CHEN Dong, LIU Shuzheng. EFFECT OF IONIZING RADIATION ON APOPTOSIS IN MOUSE PEYER'S PATCHES. [J]. Journal of Radiation Research and Radiation Processing 17(2):93-96(1999)
DOI：

LIU Jiamei, CHEN Dong, LIU Shuzheng. EFFECT OF IONIZING RADIATION ON APOPTOSIS IN MOUSE PEYER'S PATCHES. [J]. Journal of Radiation Research and Radiation Processing 17(2):93-96(1999) DOI：

摘要

采用原位末端标记（TUNEL）法研究不同剂量X射线全身照射后派伊氏板细胞凋亡的时间效应及剂量效应关系。结果表明：2Gy全身照射后派伊氏板TUNEL阳性细胞数增加；0.05Gy、0.075Gy全身照射后派伊氏板TUNEL阳性细胞数减少。提示2Gy全身照射促进细胞凋亡，而低剂量电离辐射抑制细胞凋亡。

Abstract

The relationship of time—effect and dose—effect of apoptosis in mouse Peyer s patches after whole body irradiation (WBI) with different doses of X —rays was studied by the method of TdT —mediated dUTP nick end labeling (TUNEL) . The results showed that the number of TUNEL positive cells in mouse Peyer's patches were significantly increased following WBI with 2 Gy irradiation,While the number of TUNEL positive cells were decreased after WBI with doses of 0.05Gy and 0.075Gy X —rays. The results support the view that 2Gy irradiation promote the apoptosis of immune cells and the low doses of radiationsuppress theapoptosis of immune cells.

关键词

电离辐射派伊氏板细胞凋亡原位末端标记

Keywords

Ionizing radiationPeyer's patchesApoptosisTUNEL

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