ADAPTIVE RESPONSE OF [Ca<sup>2+</sup>]<italic style="font-style: italic"><sub>i</sub></italic> AND CD71 EXPRESSION IN SPLENIC LYMPHOCYTES INDUCED BY LOW DOSE WBI WITH X-RAYS IN MICE

JU Guizhi; LUO Can; FU Haiqing; SU Xu; Fu Shibo; LIU Shuzheng

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ADAPTIVE RESPONSE OF [Ca²⁺]_i AND CD71 EXPRESSION IN SPLENIC LYMPHOCYTES INDUCED BY LOW DOSE WBI WITH X-RAYS IN MICE

更新时间：2023-04-07

- ADAPTIVE RESPONSE OF [Ca²⁺]_i AND CD71 EXPRESSION IN SPLENIC LYMPHOCYTES INDUCED BY LOW DOSE WBI WITH X-RAYS IN MICE
- Journal of Radiation Research and Radiation Processing Vol. 17, Issue 3, Pages: 159-162(1999)
- 作者机构：
  
  1.白求恩医科大学卫生部放射生物实验室　长春　130021
- 作者简介：
- 基金信息：
  
  the National Natural Science Foundation of China(3917275)
- DOI：
  CLC：
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JU Guizhi, LUO Can, FU Haiqing, et al. ADAPTIVE RESPONSE OF [Ca²⁺]_i AND CD71 EXPRESSION IN SPLENIC LYMPHOCYTES INDUCED BY LOW DOSE WBI WITH X-RAYS IN MICE. [J]. Journal of Radiation Research and Radiation Processing 17(3):159-162(1999)
DOI：

JU Guizhi, LUO Can, FU Haiqing, et al. ADAPTIVE RESPONSE OF [Ca²⁺]_i AND CD71 EXPRESSION IN SPLENIC LYMPHOCYTES INDUCED BY LOW DOSE WBI WITH X-RAYS IN MICE. [J]. Journal of Radiation Research and Radiation Processing 17(3):159-162(1999) DOI：

摘要

为了观察低剂量X射线全身照射诱导脾淋巴细胞内[Ca,2+,],i,及CD71表达的适应性反应。采用Fura-2负载，双波长荧光测定法检测细胞内[Ca,2+,],i,浓度。采用单克隆抗体免疫荧光标记，流式细胞术检测淋巴细胞CD71表达。发现0.075Gy低剂量预照射能明显减轻其后2.0Gy攻击剂量照射对细胞内[Ca,2+,],i,及CD71的抑制作用。低剂量辐射能诱导脾淋巴细胞[Ca,2+,],i,及CD71表达的适应性反应。此变化可能是低剂量辐射诱导T淋巴细胞免疫适应性反应的重要机制之一。

Abstract

To investigate whether adaptive response of [Ca,2+,],i, and CD71 expression in splenic lymphocytes could be induced by low dose WBI with X-ray. Fluorecent indicator fura-2 was used to measure [Ca,2+,],i, concentration in splenic lymphocytes. And flow cytometry was used to analyze CD71 expression of splenic lymphocytes for their immunofluorescence stained with monoclonal antibodies. It was found that the suppressive effect of [Ca,2+,],i, and CD71 in lymphocytes be 2.0Gy was reduced by 0.075 Gy low dose pre,-,irradiation. Adaptive response of [Ca,2+,],i, and CD71 expression of splenic lymphocytes could be incudced by low dose radiation. This finding might be one of the important mechamisms of immunological adaptive response fo T lymphocytes induced by low dose radiation.

关键词

低剂量辐射适应性反应[Ca2+]iCD71

Keywords

Low dose radiationAdaptive response[Ca2+]iCD71

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Department of Medical Radiobiology, School of Radiation Medicine and Public Health, Soochow University

Department of Radiation Biology, Norman Bethune University of Medical Sciences

Department of Toxicology, School of Public Health, Jilin University

MH Radiobiology Research Unit, School of Public Health, Jilin University

Key Laboratory of Radiobiology, Ministry of Health School of Public Health, Jilin University

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ADAPTIVE RESPONSE OF [Ca2+]i AND CD71 EXPRESSION IN SPLENIC LYMPHOCYTES INDUCED BY LOW DOSE WBI WITH X-RAYS IN MICE

DOI：

摘要

Abstract

关键词

Keywords

references

ADAPTIVE RESPONSE OF [Ca²⁺]_i AND CD71 EXPRESSION IN SPLENIC LYMPHOCYTES INDUCED BY LOW DOSE WBI WITH X-RAYS IN MICE