THE RESEARCH OF E838 IN TUMOR RADIOTHERAPY

ZHANG Yuguang; ZHANG Xinru; YAN Yujung; YANG Yi; HAN Ying; LI Zhiwang

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THE RESEARCH OF E838 IN TUMOR RADIOTHERAPY

更新时间：2023-04-07

- THE RESEARCH OF E838 IN TUMOR RADIOTHERAPY
- Journal of Radiation Research and Radiation Processing Vol. 17, Issue 4, Pages: 204-208(1999)
- 作者机构：
  
  1.中国医学科学院、中国协和医科大学放射医学研究所　天津　300192
- 作者简介：
- 基金信息：
  
  a grant from Tianjin Youth Natural Science Foundation
- DOI：
  CLC：
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ZHANG Yuguang, ZHANG Xinru, YAN Yujung, et al. THE RESEARCH OF E838 IN TUMOR RADIOTHERAPY. [J]. Journal of Radiation Research and Radiation Processing 17(4):204-208(1999)
DOI：

ZHANG Yuguang, ZHANG Xinru, YAN Yujung, et al. THE RESEARCH OF E838 IN TUMOR RADIOTHERAPY. [J]. Journal of Radiation Research and Radiation Processing 17(4):204-208(1999) DOI：

摘要

E838是雌激素类辐射防护药物。实验证明：E838对体外培养的MCF7乳腺癌细胞增殖有抑制作用，IC,50,为5.6,µ,g/mL,D,0,为3.9,µ,g/mL；它能提高荷瘤小鼠（H22腹水癌、L615白血病）的存活时间，对肿瘤细胞无辐射防护作用。无刺激或促进T739小鼠肺腺癌转移的作用，有可能成为临床放疗的辅助药物。

Abstract

E838 is a better radioprotecter that is derivative of estrogen. E838 inhibits cell proliferation of MCF7 cell line in vitro,D,0, is 3.9,µ,g/mL,IC,50, is 5.6,µ,g/mL. It also inhibits the growth of tumor bearing mice that extend the living time and enhance the effect of radiotherapy. Up till now, E838 haven't been fond the effect of stimulate and promote tumor metastasis. E838 has the possibility as an auxiliary medicine using in radiotherapy of tumors.

关键词

E838细胞增殖肿瘤转移

Keywords

E838Cell proliferationMetastatic carcinoma

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