INTERACTION OF ACCESSORY CELLS WITH SPLENIC LYMPHOCYTE AFTER WHOLE-BODY X-IRRADIATION OF MICE

SUN Yimin; LIU Shuzheng

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INTERACTION OF ACCESSORY CELLS WITH SPLENIC LYMPHOCYTE AFTER WHOLE-BODY X-IRRADIATION OF MICE

更新时间：2023-04-07

- INTERACTION OF ACCESSORY CELLS WITH SPLENIC LYMPHOCYTE AFTER WHOLE-BODY X-IRRADIATION OF MICE
- Journal of Radiation Research and Radiation Processing Vol. 18, Issue 2, Pages: 108-112(2000)
- 作者机构：
  
  1.白求恩医科大学卫生部放射生物学重点实验室　长春　130021
- 作者简介：
- 基金信息：
  
  the National Natural Science Foundation of China(39570188)
- DOI：
  CLC：
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SUN Yimin, LIU Shuzheng. INTERACTION OF ACCESSORY CELLS WITH SPLENIC LYMPHOCYTE AFTER WHOLE-BODY X-IRRADIATION OF MICE. [J]. Journal of Radiation Research and Radiation Processing 18(2):108-112(2000)
DOI：

SUN Yimin, LIU Shuzheng. INTERACTION OF ACCESSORY CELLS WITH SPLENIC LYMPHOCYTE AFTER WHOLE-BODY X-IRRADIATION OF MICE. [J]. Journal of Radiation Research and Radiation Processing 18(2):108-112(2000) DOI：

摘要

小鼠全身照射后，分别获取腹腔巨噬细胞、脾辅佐细胞及脾淋巴细胞，观察它们之间的相互作用。结果表明：75mGy照射可增强ConA刺激的淋巴细胞增殖反应，2.0Gy照射使其明显降低。5次细胞贴壁去除辅佐细胞后，其对ConA的反应性明显减弱，并且受低剂量照射后的腹腔巨噬细胞和脾辅佐细胞可以增强受低剂量照射后的T淋巴细胞的增殖反应及IL-2的产生。

Abstract

We have examined the interaction among peritoneal macrophages, splenic accessory cells and splenic lymphocytes after whole body-irradiation (WBI) of mice with X-rays. The results showd: WBI with 75mGy X-rays could increase the proliferative response of splenic lymphocytes to ConA treatment, while 2 Gy WBI decreased it. If the splenic cell suspension was depleted of adherent accessory cells, proliferative response of lymphocytes was lowered. Peritoneal macrophages and splenic accessory cells obtained from mice exposed to lower dose radiation induced increase of proliferative response of T lymphocytes to ConA and IL-2 production.

关键词

巨噬细胞脾辅佐细胞电离辐射

Keywords

MacrophagesSplenic accessory cellsIrradiation

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