THE STUDY OF THE REHABILITATE EFFECT OF G-CSF ON HEMATOLOGICAL FUNCTION AND ITS MECHANISM

ZHANG Hao; MAO Bingzhi; LUO Qinglang; XIA Zhenbiao; DONG Bo; CONG Yuwen; GUO Dehuang

您当前的位置：

首页 >

文章列表页 >

THE STUDY OF THE REHABILITATE EFFECT OF G-CSF ON HEMATOLOGICAL FUNCTION AND ITS MECHANISM

更新时间：2023-04-07

- THE STUDY OF THE REHABILITATE EFFECT OF G-CSF ON HEMATOLOGICAL FUNCTION AND ITS MECHANISM
- Journal of Radiation Research and Radiation Processing Vol. 18, Issue 2, Pages: 142-147(2000)
- 作者机构：
  
  1.军事医学科学院放射医学研究所　北京　100850
- 作者简介：
- 基金信息：
- DOI：
  CLC：
扫描看全文
ZHANG Hao, MAO Bingzhi, LUO Qinglang, et al. THE STUDY OF THE REHABILITATE EFFECT OF G-CSF ON HEMATOLOGICAL FUNCTION AND ITS MECHANISM. [J]. Journal of Radiation Research and Radiation Processing 18(2):142-147(2000)
DOI：

ZHANG Hao, MAO Bingzhi, LUO Qinglang, et al. THE STUDY OF THE REHABILITATE EFFECT OF G-CSF ON HEMATOLOGICAL FUNCTION AND ITS MECHANISM. [J]. Journal of Radiation Research and Radiation Processing 18(2):142-147(2000) DOI：

摘要

研究了粒细胞集落生长因子（G-CSF）促进受辐射小鼠造血功能恢复的作用，并对机理进行了初步探讨。结果表明：G-CSF不仅可以促进受辐射小鼠外周血细胞的恢复，促进脾脏内源性脾结节的形成，而且可以增加骨髓细胞含量和促进骨髓细胞巨噬系造血祖细胞（CFU-GM）的形成，提高受辐射小鼠的生存率，其促进辐射后机体造血功能恢复的机理是通过刺激照射后残余造血干细胞的增殖、分化，该过程需要一段较长的时间，而不是抑制照射后即刻细胞的程序性死亡。

Abstract

This article is to study the rehabilitate effects of G-CSF on hemotological function and its mechanism. The results indicate that G-CSF can not only accelerate the recovery of peripheral blood, promote the recovery of endogenous CFU-S, but also increase the number of bone marrow cell and stimulate its CFU-GM. It can raise the 30th days survival rate of irradiated mice. The mechanism is due to accelerative action on the recovery of hematological function in exposed mice. This procedure needs a long time. It is not due to the inhibitory upon programmed cell death of cells.

关键词

细胞因子重组人粒细胞集落刺激因子辐射

Keywords

CytokineG-CSFIrradiation

references

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Bioinformatic analysis of ionizing radiation on CAL-27 cells

CpG-ODN prevent pulmonary fibrosis by regulating the expression of Th1/Th2 cytokines

Mutation breeding of ethanol-producing yeast Saccharomyces cerevisiae by low-energy nitrogen ion implantation and UV rays

Recent progress of applying mesenchymal stem cells in therapy of urgent radiation damage

Effect of low dose ¹²C⁶⁺ irradiation on cell cycle and DNA damage in mouse thymus and spleen cells

Related Author

No data

Related Institution

Institute of Radiation Medicine, Fudan University

School of Stomatology, Lanzhou University

Institute of Modern Physics, Chinese Academy of Sciences

Dezhou City People's Hospital

Faculty of Naval Medicine, The Second Military Medical University

⁰