EFFECTS ON PROLIFERATION AND CELL CYCLE OF IRRADIATED KG-l CELLS STIMULTATED BY CM-CSF

GUO Dehuang; DONG Bo; WEN Gengyun; LUO Qingliang; MAO Bingzhi

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EFFECTS ON PROLIFERATION AND CELL CYCLE OF IRRADIATED KG-l CELLS STIMULTATED BY CM-CSF

更新时间：2023-04-07

- EFFECTS ON PROLIFERATION AND CELL CYCLE OF IRRADIATED KG-l CELLS STIMULTATED BY CM-CSF
- Journal of Radiation Research and Radiation Processing Vol. 18, Issue 2, Pages: 157-160(2000)
- 作者机构：
  
  1.军事医学科学院放射医学研究所　北京　100850
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GUO Dehuang, DONG Bo, WEN Gengyun, et al. EFFECTS ON PROLIFERATION AND CELL CYCLE OF IRRADIATED KG-l CELLS STIMULTATED BY CM-CSF. [J]. Journal of Radiation Research and Radiation Processing 18(2):157-160(2000)
DOI：

GUO Dehuang, DONG Bo, WEN Gengyun, et al. EFFECTS ON PROLIFERATION AND CELL CYCLE OF IRRADIATED KG-l CELLS STIMULTATED BY CM-CSF. [J]. Journal of Radiation Research and Radiation Processing 18(2):157-160(2000) DOI：

摘要

以临床上常用的细胞因子GM-CSF刺激受辐射的人髓性白血病细胞株KG-l, 观察细胞的增殖情况及周期变化。结果显示：GM -CSF刺激受辐射KG-l细胞的增殖，并且能促进细胞跳出G,0,/G,1,阻滞，对S期似有促进作用及增加G,2,/M期。对末受照射的KG-l细胞，GM-CSF刺激效应不如受照射细胞。

Abstract

In order to explore the variety of cell proliferation and cell cycle after exposure to ionizing radiation, the responses of irradiated KG-1 cells of the human myeloid leukemia stimulated by GM-CSF, the most common used cytokine in clinic, were investigated. The results showed that GM-CSF enhance KG-1 cells prolifration, reduce G0/G1 block, increase S phase and G2/M phase. The stimulation effects of the GM-CSF is more effective in irradiated group than in control group.

关键词

辐射KG-lGM-CSF细胞周期

Keywords

Radiation;KG-1 cellGM-CSFCell cycle

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