HYPERTHERMIA INDUCED CROSS-ADAPTIVE RESPONSE IN MOUSE EMBRYO TO SUBSEQUENT <sup>60</sup>Co γ RAYS EXPOSURE

RUAN Ming; LU Chunlin; YANG Yepeng; SUN Fei; HONG Min; DU Heng; LIU Jingyuan

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HYPERTHERMIA INDUCED CROSS-ADAPTIVE RESPONSE IN MOUSE EMBRYO TO SUBSEQUENT ⁶⁰Co γ RAYS EXPOSURE

更新时间：2023-04-07

- HYPERTHERMIA INDUCED CROSS-ADAPTIVE RESPONSE IN MOUSE EMBRYO TO SUBSEQUENT ⁶⁰Co γ RAYS EXPOSURE
- Journal of Radiation Research and Radiation Processing Vol. 18, Issue 3, Pages: 223-225(2000)
- 作者机构：
  
  1.北京医科大学公卫毒理室　北京　100083
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RUAN Ming, LU Chunlin, YANG Yepeng, et al. HYPERTHERMIA INDUCED CROSS-ADAPTIVE RESPONSE IN MOUSE EMBRYO TO SUBSEQUENT ⁶⁰Co γ RAYS EXPOSURE. [J]. Journal of Radiation Research and Radiation Processing 18(3):223-225(2000)
DOI：

RUAN Ming, LU Chunlin, YANG Yepeng, et al. HYPERTHERMIA INDUCED CROSS-ADAPTIVE RESPONSE IN MOUSE EMBRYO TO SUBSEQUENT ⁶⁰Co γ RAYS EXPOSURE. [J]. Journal of Radiation Research and Radiation Processing 18(3):223-225(2000) DOI：

摘要

为研究高温复合电离辐射对小鼠早期的胚胎效应，选用以孕9d LACA小鼠，给予42℃10min 1.0Gy ,60,Co γ射线处理。于孕后第18天取出胎鼠，观察生长发育情况，测量脑DNA、RNA、蛋白质含量。结果显示，与对照组相比1.0Gy胚鼠组发育迟缓，核酸、蛋白质含量明显下降，而42℃组变化不显著，42℃+1.0Gy照射组损伤程度介于42℃组与1.0Gy组之间。这表明1.0Gy ,60,Co ,γ,线使胎鼠生长发育受到影响。而预先42℃ 10min处理孕鼠，其胎仔对随后较大剂量电离辐射打击表现出交叉适应性反应。

Abstract

To study the effects of heat and ionizing radiation on mouse embryos, the LACA mice were exposed to 42℃ for 10min and 1.0Gy ,60,Co γ rays on the 9th day after gestation, and development of mouse embryos were observed and the contents of DNA, RNA and protein in the brains of mouse embryos were measured on the 18th day after gestation. Results demonstrated that 1.0Gy ,60,Co γ rays irradiation, compared with control, could induce the development retardation for mouse embryos, and the contents of nucleic acids and protein in brains of mouse embryos irradiated were lwss. Meanwhile 42℃ exposure induce insignificant or less effects. The mouse group with 42℃ treatment followed by 1.0Gy ,60,Co irradiation showed the efffects at the level between the groups with 42℃ and 1.0Gy irradiation. Thus, exposure of mouse embryos to 42℃ for 10min prior to irradiation may be could induce their adaptive response to irradiation.

关键词

电离辐射高温胚胎核酸蛋白质

Keywords

Ionizing radiationHyperthermiaMouse embryosNucleic acidsProtein

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HYPERTHERMIA INDUCED CROSS-ADAPTIVE RESPONSE IN MOUSE EMBRYO TO SUBSEQUENT 60Co γ RAYS EXPOSURE

DOI：

摘要

Abstract

关键词

Keywords

references

HYPERTHERMIA INDUCED CROSS-ADAPTIVE RESPONSE IN MOUSE EMBRYO TO SUBSEQUENT ⁶⁰Co γ RAYS EXPOSURE