STUDY ON DNA DAMAGE OF LYMPHOCYTES IN RATS EXPOSED TO RADON AND ITS PROGENY

TONG Jian; HONG Chengjiao; WANG Jing; FU Chunling

您当前的位置：

首页 >

文章列表页 >

STUDY ON DNA DAMAGE OF LYMPHOCYTES IN RATS EXPOSED TO RADON AND ITS PROGENY

更新时间：2023-04-07

- STUDY ON DNA DAMAGE OF LYMPHOCYTES IN RATS EXPOSED TO RADON AND ITS PROGENY
- Journal of Radiation Research and Radiation Processing Vol. 19, Issue 3, Pages: 236-238(2001)
- 作者机构：
  
  1.苏州大学核医学院　苏州　215007
- 作者简介：
- 基金信息：
- DOI：
  CLC：
扫描看全文
TONG Jian, HONG Chengjiao, WANG Jing, et al. STUDY ON DNA DAMAGE OF LYMPHOCYTES IN RATS EXPOSED TO RADON AND ITS PROGENY. [J]. Journal of Radiation Research and Radiation Processing 19(3):236-238(2001)
DOI：

TONG Jian, HONG Chengjiao, WANG Jing, et al. STUDY ON DNA DAMAGE OF LYMPHOCYTES IN RATS EXPOSED TO RADON AND ITS PROGENY. [J]. Journal of Radiation Research and Radiation Processing 19(3):236-238(2001) DOI：

摘要

将大鼠暴露于10、20和30WLM（Working level months）的氡浓度后，采用H—TdR掺入法和碱性单细胞凝胶电泳技术（SCGE）,研究吸入氡及其子体后大鼠外周血淋巴细胞的DNA损伤效应。结果表明，各暴露剂量组大鼠外周血淋巴细胞转化均显著低于对照组；淋巴细胞在碱性单细胞凝胶电泳条件下DNA的迁移距离均显著高于对照组，且呈剂量—效应关系。大鼠吸入氡及其子体可引起淋巴细胞DNA合成抑制及淋巴细胞转化能力下降。

Abstract

Male Wistar rats were exposed to 0, 10, 20, and 30 working level months(WLM) of radon and its progeny by inhalation. DNA damage of rat peripheral lymphocytes induced by radon and progeny in vivo was investigated by using ,3,H—TdrR incorporation assay and alkaline single cell gel electrophoretic technique. The CPM value of rat peripheral lymphocytes from radon exposed groups was decreased significantly compared with the control,while the tail movement of lymphocytes gel electrophoresis was increased significantly, with a dose—effect relationship. The results suggest that radon and its progeny can suppress DNA synthesis of lymphocyte, reduce transformation ability of lymphocyte and damage immune function,which are useful implications in radiation protection against radon toxicity.

关键词

氡及其子体淋巴细胞DNA损伤

Keywords

Radon and its progenyLymphocytesDNA damage

references

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Progress of research on double-strand break damage induced by heavy-ion beam radiation and repair mechanism

Research progress on the radioprotective effect of epigallocatechin gallate and its mechanism

DNA damages in Tillandsia species caused by the radioactive gas radon

Oxidative damage of DNA in lung tissue of rats exposed to radon inhalation

Study on the effect of artesunate combined with irradiation on DNA damage of HeLa and Siha cells of human cervical cancer

Related Author

No data

Related Institution

Key Laboratory of Microbial Resources Development and Utilization of Gansu Province

Lanzhou University of Technology

University of Chinese Academy of Sciences

Institute of Modern Physics, Chinese Academy of Sciences

School of Public Health Jilin University, NHC Key Laboratory of Radiobiology

⁰