THE INFLUENCE ON THE EXPRESSION OF TGF-β<sub>1</sub> AND THE CONTENTS OF COLLAGEN TYPE I AND TYPE III BY HIGH ENERGY ELECTRONS RADIATION INJURY

ZHOU Yinghui; XU Lan; WU Shiliang; SHI Ning; TU Youbin; PENG Miao

您当前的位置：

首页 >

文章列表页 >

THE INFLUENCE ON THE EXPRESSION OF TGF-β₁ AND THE CONTENTS OF COLLAGEN TYPE I AND TYPE III BY HIGH ENERGY ELECTRONS RADIATION INJURY

更新时间：2023-04-07

- THE INFLUENCE ON THE EXPRESSION OF TGF-β₁ AND THE CONTENTS OF COLLAGEN TYPE I AND TYPE III BY HIGH ENERGY ELECTRONS RADIATION INJURY
- Journal of Radiation Research and Radiation Processing Vol. 20, Issue 1, Pages: 67-71(2002)
- 作者机构：
  
  1.苏州大学生物化学及分子生物学教研室　苏州　215007
- 作者简介：
- 基金信息：
- DOI：
  CLC：
扫描看全文
ZHOU Yinghui, XU Lan, WU Shiliang, et al. THE INFLUENCE ON THE EXPRESSION OF TGF-β₁ AND THE CONTENTS OF COLLAGEN TYPE I AND TYPE III BY HIGH ENERGY ELECTRONS RADIATION INJURY. [J]. Journal of Radiation Research and Radiation Processing 20(1):67-71(2002)
DOI：

ZHOU Yinghui, XU Lan, WU Shiliang, et al. THE INFLUENCE ON THE EXPRESSION OF TGF-β₁ AND THE CONTENTS OF COLLAGEN TYPE I AND TYPE III BY HIGH ENERGY ELECTRONS RADIATION INJURY. [J]. Journal of Radiation Research and Radiation Processing 20(1):67-71(2002) DOI：

摘要

探讨了高能电子线辐射损伤后Ⅰ、Ⅲ型胶原含量的改变情况及TGF—β,1,对其的调控作用。采用电子直线加速器照射制作动物的辐射损伤模型，对NIH 3T3细胞进行照射，观察胶原总量及Ⅰ、Ⅲ型胶原含量的改变；测定损伤后细胞因子TGF—β,1,表达的变化情况。结果显示，损伤后胶原总量变化不大，而Ⅰ型胶原含量下降，Ⅲ型胶原含量上升；损伤后TGF—β,1,表达量增加。结果提示，放射性皮肤损伤引起了胶原代谢的变化，损伤后胶原代谢的调控机制中，TGF—β,1,可能起重要作用。

Abstract

To investigate the change of collagen type I and type III and the action of TGF-β,1, after high energy electrons radiation. The animal model of radiation injury was established by high energy electrons radiation produced by the linear accelerator; and irradiated NIH 3T3 cells were studied. In the experiment the contents of total collagen,collagen type Ⅰ and type III were measured. The contents of TGF—β,1, were also detected. The results showed after radiation,little change was found in the content of total collagen,but the content of collagen I decreased and the content of collagen III increased; the expression of TGF-β,1, increased. Changes in the collagen metabolism were caused by the irradiated injury of the skin; TGF—β,1, may be essential in the regulation of the collagen metabolism.

关键词

电子辐射损伤胶原TGF—β1

Keywords

ElectronRadiation injuryCollagenTGF-β1

references

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Protective effects of a Chinese medicinal formula on the spleen of irradiated mice

Protective effect of fructus sophorae genistein on radiation-induced intestinal injury

Changes of PIG3 and GADD45 gene expression induced by ⁶⁰Co γ-rays in lymphoblastoid cells

Expression of calcium-binding protein S100A8 in bone marrow cells of mice with radiation injury and it’s effect

Advances in research of radioprotectant

Related Author

No data

Related Institution

Hubei University of Arts and Science, Xiangyang

Panzhihua Health Commission

Naval Medical Center of the PLA

Clinical Laboratory, Hospital of Navy

Department of Biopharmaceutics, School of Pharmacy, The Fourth Military Medical University

⁰

THE INFLUENCE ON THE EXPRESSION OF TGF-β1 AND THE CONTENTS OF COLLAGEN TYPE I AND TYPE III BY HIGH ENERGY ELECTRONS RADIATION INJURY

DOI：

摘要

Abstract

关键词

Keywords

references

THE INFLUENCE ON THE EXPRESSION OF TGF-β₁ AND THE CONTENTS OF COLLAGEN TYPE I AND TYPE III BY HIGH ENERGY ELECTRONS RADIATION INJURY