THE EFFECTS OF DP AND AMP ON IMMUNE FUNCTIONS IN IRRADIATED MICE

BU Guilan; PIAO Chunji; JIN Yuke

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THE EFFECTS OF DP AND AMP ON IMMUNE FUNCTIONS IN IRRADIATED MICE

更新时间：2023-04-13

- THE EFFECTS OF DP AND AMP ON IMMUNE FUNCTIONS IN IRRADIATED MICE
- Journal of Radiation Research and Radiation Processing Vol. 18, Issue 4, Pages: 304-307(2000)
- 作者机构：
  
  1.白求恩医科大学放射医学研究所　长春　130021
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BU Guilan, PIAO Chunji, JIN Yuke. THE EFFECTS OF DP AND AMP ON IMMUNE FUNCTIONS IN IRRADIATED MICE. [J]. Journal of Radiation Research and Radiation Processing 18(4):304-307(2000)
DOI：

BU Guilan, PIAO Chunji, JIN Yuke. THE EFFECTS OF DP AND AMP ON IMMUNE FUNCTIONS IN IRRADIATED MICE. [J]. Journal of Radiation Research and Radiation Processing 18(4):304-307(2000) DOI：

摘要

研究了预先给予双嘧达莫（DP）和腺苷一磷酸（AMP）对不同剂量X射线照射小鼠免疫功能的影响。采用BALB/C纯系小鼠给予一次性不同剂量（0、1、2、4Gy）X射线照射。照射前给予DP2mg和AMP5mg，检测胸腺细胞自发增殖反应能力和脾细胞对ConA的增殖反应能力的变化。结果表明：单纯给予DP+AMP组胸腺自发增殖反应能力和脾细胞对ConA的增殖反应能力较对照组明显下降，但1Gy和2Gy X射线照射前预先给予DP和AMP能显著增强小鼠胸腺自发增殖反应能力和脾淋巴细胞对ConA诱导的增殖反应能力。

Abstract

The effects of DP and AMP on the immune function in X-ray irradiated mice with different doses were studied in this dissertation.Mice(BALB/C) were irradiated with different doses(0, 1, 2, 4Gy) of X-rays.The spontanous proliferation of thymocytes and ConA-induced proliferation reaction of splenocytes in mice pretreated with DP(2mg) and AMP(5mg) were detected. The results were as follows:the spontanous proliferation of the thymocytes and the ConA-induced proliferation reaction of splenocytes in mice injected with DP and AMP decreased markdely, but increased significantly in mice treated with DP and AMP prior to irradiation by 1Gy and 2Gy X-rays.

关键词

双嘧达莫腺苷一磷酸电离辐射免疫功能

Keywords

DPAMPIonizing radiationImmune function

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