RADIOTOXICITY OF α-EMITTER <sup>211</sup>At FOR TESTES AND ITS LD<sub>50</sub> IN MICE

Liu Ning; Jin Jiannan; Xia Qingjie; Zhang Shuyuan

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RADIOTOXICITY OF α-EMITTER ²¹¹At FOR TESTES AND ITS LD₅₀ IN MICE

更新时间：2023-04-18

- RADIOTOXICITY OF α-EMITTER ²¹¹At FOR TESTES AND ITS LD₅₀ IN MICE
- Journal of Radiation Research and Radiation Processing Vol. 16, Issue 2, Pages: 102-105(1998)
- 作者机构：
  
  1.四川大学原子核科学技术研究所　辐射物理及技术国家教委开放实验室　成都　610064
- 作者简介：
- 基金信息：
  
  State Education Commission of China
- DOI：
  CLC：
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Liu Ning, Jin Jiannan, Xia Qingjie, et al. RADIOTOXICITY OF α-EMITTER ²¹¹At FOR TESTES AND ITS LD₅₀ IN MICE. [J]. Journal of Radiation Research and Radiation Processing 16(2):102-105(1998)
DOI：

Liu Ning, Jin Jiannan, Xia Qingjie, et al. RADIOTOXICITY OF α-EMITTER ²¹¹At FOR TESTES AND ITS LD₅₀ IN MICE. [J]. Journal of Radiation Research and Radiation Processing 16(2):102-105(1998) DOI：

摘要

研究了单次腹腔注射离子型Na ,211,At对NIH小白鼠睾丸生殖细胞辐射损伤的影响，并测定了Na ,211,At对NIH小鼠的LD,50,/7。结果表明：注射5.55×10,5,Bq的,211,At在30d内可使精子耗竭。,211,At电离辐射能够显著降低睾丸的质量，对生殖细胞和支持细胞有明显的辐射损伤作用。采用点斜法计算得,211,At对小鼠的半致死剂量LD,50,/7为8.14×10,4,Bq/g。

Abstract

The radiotoxicity of α-emitter ,211,At for testes in NIH strain mice was investigated by a singular i.p. injection with 5.55×10,5, Bq of Na ,211,At, and the histopathological change of testicular cells was observed. Testes mass decreased rapidly at 6~30 days post-injection. Histopathological observation revealed that some cells of interstitial tissue are irradiated to death at 6 days, the semininferous tubules become empty at 30 days post-injection, and there is no spermatogenesis any more at this time. Additionally, the lethal dose (LD,50,) of ,211,At in the mice was investigated also by i.p injection and a LD,50,/7 of 8.14×10,4,Bq/g was measured.

关键词

211At小鼠睾丸辐射损伤LD50

Keywords

211AtMiceTestisRadiotoxicityLD50

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RADIOTOXICITY OF α-EMITTER 211At FOR TESTES AND ITS LD50 IN MICE

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摘要

Abstract

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RADIOTOXICITY OF α-EMITTER ²¹¹At FOR TESTES AND ITS LD₅₀ IN MICE