EFFECT OF LOW DOSE IRRADIATION ON SUBSETS OF T-LYMPHOCYTE OF PERIPHERAL BLOOD, SPLEEN AND TUMOR TISSUE
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EFFECT OF LOW DOSE IRRADIATION ON SUBSETS OF T-LYMPHOCYTE OF PERIPHERAL BLOOD, SPLEEN AND TUMOR TISSUE
Journal of Radiation Research and Radiation ProcessingVol. 16, Issue 2, Pages: 113-116(1998)
作者机构:
1.苏州医学院附属第一医院放疗科 苏州 215006
2.苏州医学院放射生物学教研室 苏州 215007
作者简介:
基金信息:
The Sciene Foundation of Suzhou Medical College
DOI:
CLC:
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Zou Huawei, Su Liaoyuan, Tian Hailin. EFFECT OF LOW DOSE IRRADIATION ON SUBSETS OF T-LYMPHOCYTE OF PERIPHERAL BLOOD, SPLEEN AND TUMOR TISSUE. [J]. Journal of Radiation Research and Radiation Processing 16(2):113-116(1998)
DOI:
Zou Huawei, Su Liaoyuan, Tian Hailin. EFFECT OF LOW DOSE IRRADIATION ON SUBSETS OF T-LYMPHOCYTE OF PERIPHERAL BLOOD, SPLEEN AND TUMOR TISSUE. [J]. Journal of Radiation Research and Radiation Processing 16(2):113-116(1998)DOI:
EFFECT OF LOW DOSE IRRADIATION ON SUBSETS OF T-LYMPHOCYTE OF PERIPHERAL BLOOD, SPLEEN AND TUMOR TISSUE
Purpose: In order to understand the mechanism of the stimulation effects of low dose radiation (LDR) , we observed the immune changes of T-lymphocyte subsets. Meteria and methods: Whole body of BALB/C bring-tumor mice were exposed to the doses of 5, 10,20 and 50cGy γ-rays. The changes of T-lymphocyte subsets in peripheral blood, spleen and tumor-infiltrating lymphocyte (TIL) were studied with flow cytometry (FCM) . Results: The ratio of ,http://html.publish.founderss.cn/rc-pub/api/common/picture?pictureId=42489940&type=,http://html.publish.founderss.cn/rc-pub/api/common/picture?pictureId=42489959&type=,http://html.publish.founderss.cn/rc-pub/api/common/picture?pictureId=42489950&type=, remarkably increased in the peripheral blood and spleen (p,<,0.01) and the ratio of ,http://html.publish.founderss.cn/rc-pub/api/common/picture?pictureId=42489953&type=,http://html.publish.founderss.cn/rc-pub/api/common/picture?pictureId=42489955&type=,http://html.publish.founderss.cn/rc-pub/api/common/picture?pictureId=42489954&type=, further decread in the TIL group of mice exposed 10cGy (,p,<,0.05) . Conclution: We suggested that the immune functions were promoted by the stimulating effects of LDR of γ-rays in the bodies of the bring-tumor mice. CTL, expressing ,http://html.publish.founderss.cn/rc-pub/api/common/picture?pictureId=42489956&type=,http://html.publish.founderss.cn/rc-pub/api/common/picture?pictureId=42489973&type=,http://html.publish.founderss.cn/rc-pub/api/common/picture?pictureId=42489957&type=, molecules, were concentrated in the tumor tissues and they carried out the killing function to the tumor cells.
关键词
低剂量电离辐射T淋巴细胞亚型肿瘤免疫免疫调节
Keywords
Low dose radiationSubset of T-lymphocyteTumor immunity