MORPHOLOGICAL STUDIES ON APOPTOSIS IN IMMUNE CELLS INDUCED BY <sup>235</sup>U AND THE RADIOPROTECTION OF IL-2 AND IL-6

Zhu Shoupeng; Zhang Lansheng; Fu Qiang

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MORPHOLOGICAL STUDIES ON APOPTOSIS IN IMMUNE CELLS INDUCED BY ²³⁵U AND THE RADIOPROTECTION OF IL-2 AND IL-6

更新时间：2023-04-18

- MORPHOLOGICAL STUDIES ON APOPTOSIS IN IMMUNE CELLS INDUCED BY ²³⁵U AND THE RADIOPROTECTION OF IL-2 AND IL-6
- Journal of Radiation Research and Radiation Processing Vol. 16, Issue 4, Pages: 241-245(1998)
- 作者机构：
  
  1.苏州医学院放射医学系　苏州　215007
- 作者简介：
- 基金信息：
  
  The General Company of Nuclear Industry Foundation
- DOI：
  CLC：
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Zhu Shoupeng, Zhang Lansheng, Fu Qiang. MORPHOLOGICAL STUDIES ON APOPTOSIS IN IMMUNE CELLS INDUCED BY ²³⁵U AND THE RADIOPROTECTION OF IL-2 AND IL-6. [J]. Journal of Radiation Research and Radiation Processing 16(4):241-245(1998)
DOI：

Zhu Shoupeng, Zhang Lansheng, Fu Qiang. MORPHOLOGICAL STUDIES ON APOPTOSIS IN IMMUNE CELLS INDUCED BY ²³⁵U AND THE RADIOPROTECTION OF IL-2 AND IL-6. [J]. Journal of Radiation Research and Radiation Processing 16(4):241-245(1998) DOI：

摘要

对浓缩铀,235,U内照射人淋巴细胞白血病细胞株Molt-4细胞和巨噬细胞株Ana-1细胞诱发的细胞凋亡及细胞因子的防护作用进行了研究。实验中估算了,235,U在不同阶段培养细胞中的辐射累积吸收剂量。通过荧光显微镜形态观察，发现免疫细胞在受,235,U辐照后，可诱发明显的以核断裂和核固缩为特征的细胞凋亡。微观放射自显影研究显示，,235,U可迅速被免疫细胞吞噬，在细胞内以吞噬小泡的形式均匀地弥散于胞浆和胞核内。研究发现，IL-2和IL-6这两个细胞因子对由,235,U诱发的免疫细胞DNA链断裂具有显著的防护作用。研究结果对于临床上寻找提高内照射放射治疗病例的免疫功能措施，具有一定的价值。

Abstract

Cell apoptosis in human acute lymphoblastic cell line Molt-4 and macrophage cell line Ana1 was induced by ,235,U. The cumulative radiation absorption doses of ,235,U in cultured cells through different periods were estimated. The morphological changes in Molt-4 and Ana-1 cells were observed by fluorescence microscopy. We found that Molt-4 and Ana-1 cells,internally irradiated by ,235,U,displayed a significant nuclear fragmentation and a marked pyknosis. The microautoradiographic study showed that at first ,235,U was phagocytized by Molt-4 and Ana-1 cells,and then ,235,U was homogeneously distributed through the cells. The finding indicated that ,235,U can significantly increase the DNA fragmentation and apoptotic bodies formation in the immune cells, and this effect could be inhibited by IL-2 and IL-6. So both IL-2 and IL-6 showed radioprotective effect on Molt-4 and Ana-1 cells internally irradiated by ,235,U.

关键词

浓缩铀235U免疫细胞凋亡IL-2IL-6防护

Keywords

Enriched uranium 235UImmune cellsApoptosisIL-2IL-6Radioprotection

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MORPHOLOGICAL STUDIES ON APOPTOSIS IN IMMUNE CELLS INDUCED BY 235U AND THE RADIOPROTECTION OF IL-2 AND IL-6

DOI：

摘要

Abstract

关键词

Keywords

references

MORPHOLOGICAL STUDIES ON APOPTOSIS IN IMMUNE CELLS INDUCED BY ²³⁵U AND THE RADIOPROTECTION OF IL-2 AND IL-6