A STUDY OF RADIATION INDUCED MALFORMATION AND CANCER IN MICE IRRADIATED IN THE PERIOD OF ORGANOGENESIS

Zhou Jiwen; Wang Jixian; Deng Bifang; Wang Sulan

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A STUDY OF RADIATION INDUCED MALFORMATION AND CANCER IN MICE IRRADIATED IN THE PERIOD OF ORGANOGENESIS

更新时间：2023-04-23

- A STUDY OF RADIATION INDUCED MALFORMATION AND CANCER IN MICE IRRADIATED IN THE PERIOD OF ORGANOGENESIS
- Journal of Radiation Research and Radiation Processing Vol. 2, Issue 2, Pages: 39-44(1984)
- 作者机构：
  
  1.中国医学科学院放射医学研究所
- 作者简介：
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Zhou Jiwen, Wang Jixian, Deng Bifang, et al. A STUDY OF RADIATION INDUCED MALFORMATION AND CANCER IN MICE IRRADIATED IN THE PERIOD OF ORGANOGENESIS. [J]. Journal of Radiation Research and Radiation Processing 2(2):39-44(1984)
DOI：

Zhou Jiwen, Wang Jixian, Deng Bifang, et al. A STUDY OF RADIATION INDUCED MALFORMATION AND CANCER IN MICE IRRADIATED IN THE PERIOD OF ORGANOGENESIS. [J]. Journal of Radiation Research and Radiation Processing 2(2):39-44(1984) DOI：

摘要

本文目的在于观察器官形成期小鼠胚胎的单次和分次小剂量照射后的近期和远期效应。,实验分为近期效应组，远后效应组及各自的对照组。近期效应作了单次不同剂量照射（从30～300 rad）和分次照射（计5次，每次50 rad累积剂量250 rad）,实验结果表明：胚胎器官形成期照射的近期效应：一是引起广泛的先天畸形，二是出生前存活率明显降低，死亡和吸收率明显增加。,远后效应主要是体重增长抑制与肿瘤发生率明显增高。

Abstract

The early and late effects of a single radiation dose or fractional doses on the mice during the period of organogenesis were studied.,In the early effect group, a variety of congenital defects and a great number of death in fetus were produced by γ-irradiation.,All the animals in the late effect group have been observed for two years. It was shown that the incidence of leukemia in the treated group was 2.5 times higher than that in the control group, and the average weight of the irradiated fetus decreased significantly.

关键词

辐射致癌作用畸形胚胎效应

Keywords

RadiationCarcinogensisMalformationEmbryo effect

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