EFFECTS OF GAMMA-IRRADIATION ON DNA CROSS-LINKING

Ma Yuqin; Yu Mingzhu; Song Xueling

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EFFECTS OF GAMMA-IRRADIATION ON DNA CROSS-LINKING

更新时间：2023-04-23

- EFFECTS OF GAMMA-IRRADIATION ON DNA CROSS-LINKING
- Journal of Radiation Research and Radiation Processing Vol. 2, Issue 4, Pages: 50-53(1984)
- 作者机构：
  
  1.中国科学院生物物理研究所
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Ma Yuqin, Yu Mingzhu, Song Xueling. EFFECTS OF GAMMA-IRRADIATION ON DNA CROSS-LINKING. [J]. Journal of Radiation Research and Radiation Processing 2(4):50-53(1984)
DOI：

Ma Yuqin, Yu Mingzhu, Song Xueling. EFFECTS OF GAMMA-IRRADIATION ON DNA CROSS-LINKING. [J]. Journal of Radiation Research and Radiation Processing 2(4):50-53(1984) DOI：

摘要

象DNA链断裂一样，DNA交联是一种重要的辐射损伤类型。我们研究了关于稀释溶液中DNA分子的链间交联。结果表明，DNA分子链间交联仅在辐照剂量为20～100 Gy的范围内出现。这种效应依赖于DNA的浓度和（G + C）%含量而与剂量率无关。5'-溴尿嘧啶和半胱氨酸的辐射敏化作用和保护作用也得到证实。

Abstract

DNA cross linking is an type of radiation damage as important as DNA strand-break. The DNA interstrand cross-linking in the dilute solution has been studied, and the result showed that DNA interstrand cross-linking only presented with in the irradiation dose range of 20~100 Gy. The effect depends on concentrantions and G-C percentage of DNA and is independent of dose-rate. The radioprotective effects of cysteine and radiosensitive effects of 5'-Bromouracil were demostrated as well.

关键词

γ辐射交联敏化剂保护剂

Keywords

γ-irradiationCross-linkingSensitizing agentProtective agent

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