THE EFFECTS OF VARIOUS IRRADIATION SCHEDULES ON THE HEMOPOIETIC RESIDUAL DAMAGE IN MICE

Yang Fengtong; Lu Shaoping; Peng Wenzhen; Xu Chengxiong

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THE EFFECTS OF VARIOUS IRRADIATION SCHEDULES ON THE HEMOPOIETIC RESIDUAL DAMAGE IN MICE

更新时间：2023-04-23

- THE EFFECTS OF VARIOUS IRRADIATION SCHEDULES ON THE HEMOPOIETIC RESIDUAL DAMAGE IN MICE
- Journal of Radiation Research and Radiation Processing Vol. 3, Issue 2, Pages: 27-32(1985)
- 作者机构：
  
  1.中国医学科学院放射医学研究所
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Yang Fengtong, Lu Shaoping, Peng Wenzhen, et al. THE EFFECTS OF VARIOUS IRRADIATION SCHEDULES ON THE HEMOPOIETIC RESIDUAL DAMAGE IN MICE. [J]. Journal of Radiation Research and Radiation Processing 3(2):27-32(1985)
DOI：

Yang Fengtong, Lu Shaoping, Peng Wenzhen, et al. THE EFFECTS OF VARIOUS IRRADIATION SCHEDULES ON THE HEMOPOIETIC RESIDUAL DAMAGE IN MICE. [J]. Journal of Radiation Research and Radiation Processing 3(2):27-32(1985) DOI：

摘要

研究了剂量分割对ICR/JCL和LACA小鼠的活存率，股骨中骨髓细胞（BMC）和造血干细胞（CFU-S）数，以及CFU-S自我更新能力的影响。剂量分割对小鼠的存活率有明显的影响。在18 Gy照射后2个月，接受3.0 Gy 6次照射和4.5Gy 4次照射的小鼠分别活存40%和15%，但6.0 Gy 3次照射小鼠已全数死亡。当总剂量12 Gy分割成2—4次照射时，大多数小鼠能活存5个月以上。虽然每根股骨中的BMC数在照后2个月恢复至正常或接近正常水平，但股骨CFU-S含量只相当于同令对照的40%，CFU-S自我更新能力只相当于25%。这种造血残留损伤在照后11个月时仍然存在，在不同的剂量分割组之间未见明显的差别。

Abstract

The effects of dose fractionation on the survival rate, the numbers of bone marrow cells (BMC) and hemopoietic stem cells (CFU-S) per femur, and the self-renewal capacity of the CFU-S in ICR/JCL and LACA mice were investigated. It was found that dose fractionation affected the mouse survival rate significantly. At 2 months after 18 Gy irradiation, the survival rates of mice received 6 doses of 3.0 Gy and 4 doses of 4.5 Gy were about 40% and 15% respectively, but all mice died after 3 doses of 6.0 Gy. When the total dose of 12 Gy was split into 2-4 fractions, most mice survived more than 5 months. Although the number of BMC per femur recovered to normal or near normal level after 2 months of irradiation, the number of CFU-S per femur was only about 40% and the self-renewal capacity of the CFU-S was only about 25% of the age-paired controls. This kind of hemopoietic residual damage remained unchanged up to 11 months after irradiation and no significant differences were found among the various dose fractionation groups.

关键词

辐射残留损伤造血干细胞剂量分割

Keywords

Residual radiation injuryHemopoietic stem cellDose fractionation

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