STUDIES ON RADIOPROTECTION MECHANISM BY SYNTHETIC SINAPIC ACID AMINE SALT DERIVATIVES

Huang Zhentong; Wang Likang; Dong Xin; Lin Nianyun

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STUDIES ON RADIOPROTECTION MECHANISM BY SYNTHETIC SINAPIC ACID AMINE SALT DERIVATIVES

更新时间：2023-04-23

- STUDIES ON RADIOPROTECTION MECHANISM BY SYNTHETIC SINAPIC ACID AMINE SALT DERIVATIVES
- Journal of Radiation Research and Radiation Processing Vol. 4, Issue 3, Pages: 39-44(1986)
- 作者机构：
  
  1.上海市放射医学研究所
  2.中国科学院上海原子核研究所
- 作者简介：
- 基金信息：
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Huang Zhentong, Wang Likang, Dong Xin, et al. STUDIES ON RADIOPROTECTION MECHANISM BY SYNTHETIC SINAPIC ACID AMINE SALT DERIVATIVES. [J]. Journal of Radiation Research and Radiation Processing 4(3):39-44(1986)
DOI：

Huang Zhentong, Wang Likang, Dong Xin, et al. STUDIES ON RADIOPROTECTION MECHANISM BY SYNTHETIC SINAPIC ACID AMINE SALT DERIVATIVES. [J]. Journal of Radiation Research and Radiation Processing 4(3):39-44(1986) DOI：

摘要

为了寻找有效的辐射损伤防护药，改进及新合成芥子酸及胺盐衍生物，用ESR波谱研究电子从靶分子脱氧胸腺嘧啶核苷酸（dTMP）向芥子酸长程转移的保护机理。经辐照小鼠的试验表明：辐照损伤引起的外周血小板下降症可以被芥子酸胺盐衍生物保护。并报道了芥子酸类衍生物的红外及核磁共振光谱。

Abstract

In order to find more effective radioprotector, an improved new method to synthesis sinapic acid and its amine salt derivatives has been reported, and the study of ESR spectra from sinapic acid-dTMP with molar ratio 1:10 irradiated and recorded at 77 K has confirmed the long range electron transfer from thymine of dTMP to sinapic acid:,http://html.publish.founderss.cn/rc-pub/api/common/picture?pictureId=42648498&type=,http://html.publish.founderss.cn/rc-pub/api/common/picture?pictureId=42648500&type=,http://html.publish.founderss.cn/rc-pub/api/common/picture?pictureId=42648509&type=,also, the radioprotective effect of sinapic acid amine salt derivatives on irradiated mice(500 rad.) has been shown in increasing peripheral platelet count with significance of statistics. The I. R and NMR spectra of sinapic acid derivatives also have been reported.

关键词

辐射防护药芥子酸合成电荷转移ESR波谱提高血小板

Keywords

RadioprotectorSynthesis of Sinapic AcidCharge TransferESRPlatelet Increasing

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