DOMINANT LETHAL MUTATION INDUCED BY CONTINUOUS IRRADIATION OF <sup>60</sup>CO GAMMA RAYS IN MICE

Zhou Xiangyan; Dong Jinchan

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DOMINANT LETHAL MUTATION INDUCED BY CONTINUOUS IRRADIATION OF ⁶⁰CO GAMMA RAYS IN MICE

更新时间：2023-04-23

- DOMINANT LETHAL MUTATION INDUCED BY CONTINUOUS IRRADIATION OF ⁶⁰CO GAMMA RAYS IN MICE
- Journal of Radiation Research and Radiation Processing Vol. 4, Issue 4, Pages: 8-11(1986)
- 作者机构：
  
  1.中国预防医学中心工业卫生实验所
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Zhou Xiangyan, Dong Jinchan. DOMINANT LETHAL MUTATION INDUCED BY CONTINUOUS IRRADIATION OF ⁶⁰CO GAMMA RAYS IN MICE. [J]. Journal of Radiation Research and Radiation Processing 4(4):8-11(1986)
DOI：

Zhou Xiangyan, Dong Jinchan. DOMINANT LETHAL MUTATION INDUCED BY CONTINUOUS IRRADIATION OF ⁶⁰CO GAMMA RAYS IN MICE. [J]. Journal of Radiation Research and Radiation Processing 4(4):8-11(1986) DOI：

摘要

本文介绍了成年雌性和雄性NIH小鼠分别接受,60,Coγ线连续照射诱发卵母细胞和精细胞显性致死突变的结果。二种小鼠布放在4.3克镭当量的钴源室内，连续照射10天，雌鼠接受的累积剂量分别为0.396、0.506、0.836、1.232、2.024 Gy，诱发植入前丢失数为1.2220、0.8095、1.4783、2.2308、3.7143；雄鼠接受的累积剂量分别为0.462，0.594, 0.968, 1.628, 2.552 Gy，诱发植入前丢失数为0.0345、0.0690、1.1379、2.1538、2.2308。实验结果表明：卵母细胞和精细胞的植入前丢失数与剂量之间均为线性关系，两斜率之比为1.66。说明在相同照射条件下，诱发卵母细胞突变率比精细胞敏感1.66倍。

Abstract

Female and male mice were exposed to ,60,Co gamma rays for 10 days, the accumulative doses were 0.396-2.024 and 0.462-2.552 Gy respectively. The number of dominant lethal mutations was calculated as follows: PRE=CL-(ED+LD+VIA) . The results showed that Preimplantation Loss (PRE) ranged from 1.222 to 3.714 for female mice and 0.0345 to 2.2308 for male mice in both cases a linear dose-effect relationship was observed. The PRE of oocytes is 1.66 times higher than that of spermatids.

关键词

氚水60Coγ线显性致死突变植入前丢失

Keywords

tritiated water60Co gamma raysdominant lethal mutationpreimplantation loss

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DOMINANT LETHAL MUTATION INDUCED BY CONTINUOUS IRRADIATION OF 60CO GAMMA RAYS IN MICE

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DOMINANT LETHAL MUTATION INDUCED BY CONTINUOUS IRRADIATION OF ⁶⁰CO GAMMA RAYS IN MICE