RADIOSENSITIZATION OF HYPOXIC L<sub>7712</sub> CELLS BY METRONIDAZOLE DERIVATIVE (CM)

Yang Lixi; Zheng Xiulong

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RADIOSENSITIZATION OF HYPOXIC L₇₇₁₂ CELLS BY METRONIDAZOLE DERIVATIVE (CM)

更新时间：2023-04-23

- RADIOSENSITIZATION OF HYPOXIC L₇₇₁₂ CELLS BY METRONIDAZOLE DERIVATIVE (CM)
- Journal of Radiation Research and Radiation Processing Vol. 5, Issue 1, Pages: 33-37(1987)
- 作者机构：
  
  1.第二军医大学
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Yang Lixi, Zheng Xiulong. RADIOSENSITIZATION OF HYPOXIC L₇₇₁₂ CELLS BY METRONIDAZOLE DERIVATIVE (CM). [J]. Journal of Radiation Research and Radiation Processing 5(1):33-37(1987)
DOI：

Yang Lixi, Zheng Xiulong. RADIOSENSITIZATION OF HYPOXIC L₇₇₁₂ CELLS BY METRONIDAZOLE DERIVATIVE (CM). [J]. Journal of Radiation Research and Radiation Processing 5(1):33-37(1987) DOI：

摘要

本文报道了用马血清代替小牛血清改进和建立了能用于检测L,7712,细胞存活率的ADC法。并用此法研究证明了我们合成的甲硝羟乙唑衍生物（CM）对离体乏氧L,7712,细胞有明显的辐射增敏作用，其SER值为2左右，较原化合物灭滴灵的SER（1.2）约提高67 %。CM对缺氧细胞存活率的抑制作用比有氧下强。与前文报道的CM对荷瘤小鼠S,180,缺氧下照射有辐射增敏作用及对鼠乏氧S,180,生长有抑制作用的结果一致。作者对台盼蓝染色法和ADC法检测细胞存活率作了比较。

Abstract

The modified ADC method which can be used in measuring the survival fraction of L,7712, cells was established using horse serum instead of calf serum. It demonstrated the obvious radiosensitizing effect of metronidazole derivative (CM)on in vitro hypoxic L,7712, cells. Its SER was about 2, and was about 67 percent higher than SER (1.2) of the original compound, metronidazole. CM was found to be stronger under hypoxic condition than under aerated condition in the inhibition of cell survival fraction. It was consistent with the results of the preceeding paper that CM showed a strong ability to sensitize sarcoma 180 to radiation and to inhibit the growth of sarcoma 180 under hypoxic condition. Using trypan blue staining method and the ADC method to observe cell survival were compared.

关键词

CML7712细胞扩散盒存活曲线SER

Keywords

CML7712 cellsdiffusion chambersurvival curveSER

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Cancer Institute (Hospital) CAMS

nd Military Medical University

第二军医大学电子计算机教研室

Second Military Medical College

Laboratory of Biophysics, Fudan University

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RADIOSENSITIZATION OF HYPOXIC L7712 CELLS BY METRONIDAZOLE DERIVATIVE (CM)

DOI：

摘要

Abstract

关键词

Keywords

references

RADIOSENSITIZATION OF HYPOXIC L₇₇₁₂ CELLS BY METRONIDAZOLE DERIVATIVE (CM)