STUDY ON THE RADIOSENSITIZATION OF AT<sub>1727</sub> ON HUMAN LUNG ADENOCARCINOMA CELL LINE SPC-A-1

Lin Wanmin; Ma Chengwu; Luo Zuyu; Fan Wenlin; Chen Yixin; Liang Jie

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STUDY ON THE RADIOSENSITIZATION OF AT₁₇₂₇ ON HUMAN LUNG ADENOCARCINOMA CELL LINE SPC-A-1

更新时间：2023-04-23

- STUDY ON THE RADIOSENSITIZATION OF AT₁₇₂₇ ON HUMAN LUNG ADENOCARCINOMA CELL LINE SPC-A-1
- Journal of Radiation Research and Radiation Processing Vol. 5, Issue 3, Pages: 58-62(1987)
- 作者机构：
  
  1.复旦大学
- 作者简介：
  
  +Undergraduated-students of the 5 th grade of biophysics section.
  +Undergraduated-students of the 5 th grade of biophysics section.
  +Undergraduated-students of the 5 th grade of biophysics section.
- 基金信息：
- DOI：
  CLC：
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Lin Wanmin, Ma Chengwu, Luo Zuyu, et al. STUDY ON THE RADIOSENSITIZATION OF AT₁₇₂₇ ON HUMAN LUNG ADENOCARCINOMA CELL LINE SPC-A-1. [J]. Journal of Radiation Research and Radiation Processing 5(3):58-62(1987)
DOI：

Lin Wanmin, Ma Chengwu, Luo Zuyu, et al. STUDY ON THE RADIOSENSITIZATION OF AT₁₇₂₇ ON HUMAN LUNG ADENOCARCINOMA CELL LINE SPC-A-1. [J]. Journal of Radiation Research and Radiation Processing 5(3):58-62(1987) DOI：

摘要

乙双吗啉（AT,1727,）是我国自行合成的哌嗪二酮类抗肿瘤药物，它的放射增敏性近年来引起了各方面的关注。本文以人肺腺癌细胞系SPC-A-1为材料，用体外细胞集落形成法研究了乙双吗啉在乏氧条件下的辐射增敏性，结果表明当药物浓度为0.15 m mol/L时，增敏比为1.33。对现有资料进行分析，提出乙双吗啉可能以某种方式作用于乏氧的肿瘤细胞。

Abstract

Bimolane (AT,1727,), a new antitumour drug, was synthesized in China. Of late years, attention has been paid to the radiosensitizing activity of AT,1727,. In present study, this effect has been studied with hypoxic human lung adeno-carcinoma SPC-A-1 using colony formation assay ,in vitro., The restlt obtained showed that the SER(Sensitivity Enhancement Ratio) was 1.33 when the concentration of AT,1727, was 0.15 m mol/L.,Basing on the analysis of some results including those of solid tumour of mice, it is reasonable that AT,1727, has radiosensitizing effect on hypoxic tumour cells.

关键词

乙双吗啉（AT1727）SPC-A-1细胞细胞毒乏氧细胞辐射增敏剂增敏比（SER）

Keywords

Bimolane (AT1727)SPC-A-1 cell lineCytotoxicityHypoxic cell radiosensitizerSER

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STUDY ON THE RADIOSENSITIZATION OF AT1727 ON HUMAN LUNG ADENOCARCINOMA CELL LINE SPC-A-1

DOI：

摘要

Abstract

关键词

Keywords

references

STUDY ON THE RADIOSENSITIZATION OF AT₁₇₂₇ ON HUMAN LUNG ADENOCARCINOMA CELL LINE SPC-A-1