RETENTION AND TRANSFERENCE OF ENRICHED URANIUM (UO<sub>2</sub> F<sub>2</sub>) ADMINISTERED FOR ONCE OR CONSECUTIVE DAYS AND ITS MUTAGENIC EFFECT ON PERIPHERAL BLOOD LYMPHOCYTES

Zhu Shoupeng; Zheng Siying; Wang Chongdao; Cao Genfa; Sun Baofu

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RETENTION AND TRANSFERENCE OF ENRICHED URANIUM (UO₂ F₂) ADMINISTERED FOR ONCE OR CONSECUTIVE DAYS AND ITS MUTAGENIC EFFECT ON PERIPHERAL BLOOD LYMPHOCYTES

更新时间：2023-04-23

- RETENTION AND TRANSFERENCE OF ENRICHED URANIUM (UO₂ F₂) ADMINISTERED FOR ONCE OR CONSECUTIVE DAYS AND ITS MUTAGENIC EFFECT ON PERIPHERAL BLOOD LYMPHOCYTES
- Journal of Radiation Research and Radiation Processing Vol. 6, Issue 1, Pages: 6-10(1988)
- 作者机构：
  
  1.苏州医学院
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Zhu Shoupeng, Zheng Siying, Wang Chongdao, et al. RETENTION AND TRANSFERENCE OF ENRICHED URANIUM (UO₂ F₂) ADMINISTERED FOR ONCE OR CONSECUTIVE DAYS AND ITS MUTAGENIC EFFECT ON PERIPHERAL BLOOD LYMPHOCYTES. [J]. Journal of Radiation Research and Radiation Processing 6(1):6-10(1988)
DOI：

Zhu Shoupeng, Zheng Siying, Wang Chongdao, et al. RETENTION AND TRANSFERENCE OF ENRICHED URANIUM (UO₂ F₂) ADMINISTERED FOR ONCE OR CONSECUTIVE DAYS AND ITS MUTAGENIC EFFECT ON PERIPHERAL BLOOD LYMPHOCYTES. [J]. Journal of Radiation Research and Radiation Processing 6(1):6-10(1988) DOI：

摘要

研究发现，当浓缩铀UO,2,F,2,单次或多次为机体摄入后，都观察到在体内蓄积最高的器官是肾脏，其次是骨骼，再则为肝脏，而在其余器官组织中含量甚微。实验观察表明，无论机体是单次或多次摄入浓缩铀，其在体内呈现的选择性蓄积特性与天然铀是一致的。,浓缩铀UO,2,F,2,在体内的蓄积动态是，在肾脏和肝脏中迅速出现蓄积高峰，并随观察时间的延长而逐渐降低。至于在骨骼中则随着观察时间的增长而持续升高。浓缩铀UO,2,F,2,诱发的血淋巴细胞畸变效应，可随摄入体内的剂量增大而血细胞畸变率亦增高。且可在一个细胞中观察到有两个畸变发生，同时细胞分裂指数亦受到明显抑制。

Abstract

Retention and transference of enriched uranium (UO,2,F,2,) were observed after iv once 20 mg/kg and ip 15 mg/kg qd× 3d to Wistar male rats. The dynamic retention of radioactivity in the body showed that enriched uranium (UO,2,F,2,) was chiefly localized in kidney, and then in skeletion and liver. The activity of enriched oranium(UO,2,F,2,) in skeleton rose steadily while the concentration in kidney and liver were droped. It was concluded that the retention peculiarity of enriched uranium was equal to the natural uranium.,When enriched uranium(UO,2,F,2,)was accumulated in organism, it caused chromosome aberration on peripheral blood lymphocytes. Results indicated that the chromosome aberration rates were elevated when the dose of enriched uranium(UO,2,F,2,) was enlarged. At the same time the cell division was depressed.

关键词

浓缩铀氟化铀酰蓄积染色体畸变

Keywords

enriched uraniumUO2F2retentionchromosome aberration

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RETENTION AND TRANSFERENCE OF ENRICHED URANIUM (UO2 F2) ADMINISTERED FOR ONCE OR CONSECUTIVE DAYS AND ITS MUTAGENIC EFFECT ON PERIPHERAL BLOOD LYMPHOCYTES

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RETENTION AND TRANSFERENCE OF ENRICHED URANIUM (UO₂ F₂) ADMINISTERED FOR ONCE OR CONSECUTIVE DAYS AND ITS MUTAGENIC EFFECT ON PERIPHERAL BLOOD LYMPHOCYTES