COMPARISON STUDY OF DNA SYNTHESIS, SINGLE STRAND BREAKS AND REPAIR IN T AND B LYMPHOCYTES AFTER <sup>60</sup>Co GAMMA-RAYS IRRADIATION

Yin Jianlin; Su Liaoyuan; Liu Keliand

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COMPARISON STUDY OF DNA SYNTHESIS, SINGLE STRAND BREAKS AND REPAIR IN T AND B LYMPHOCYTES AFTER ⁶⁰Co GAMMA-RAYS IRRADIATION

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- COMPARISON STUDY OF DNA SYNTHESIS, SINGLE STRAND BREAKS AND REPAIR IN T AND B LYMPHOCYTES AFTER ⁶⁰Co GAMMA-RAYS IRRADIATION
- Journal of Radiation Research and Radiation Processing Vol. 6, Issue 1, Pages: 33-37(1988)
- 作者机构：
  
  1.苏州医学院，苏州
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Yin Jianlin, Su Liaoyuan, Liu Keliand. COMPARISON STUDY OF DNA SYNTHESIS, SINGLE STRAND BREAKS AND REPAIR IN T AND B LYMPHOCYTES AFTER ⁶⁰Co GAMMA-RAYS IRRADIATION. [J]. Journal of Radiation Research and Radiation Processing 6(1):33-37(1988)
DOI：

Yin Jianlin, Su Liaoyuan, Liu Keliand. COMPARISON STUDY OF DNA SYNTHESIS, SINGLE STRAND BREAKS AND REPAIR IN T AND B LYMPHOCYTES AFTER ⁶⁰Co GAMMA-RAYS IRRADIATION. [J]. Journal of Radiation Research and Radiation Processing 6(1):33-37(1988) DOI：

摘要

本文采用滤膜法和碱洗脱法比较研究了γ线照射后T、B淋巴细胞DNA合成、ssb（单链断裂）及修复能力。B淋巴细胞DNA合成明显低于T淋巴细胞；虽两种细胞产生DNA ssb没有差别，但其修复能力，T淋巴细胞高于B淋巴细胞。说明在分子水平上，B淋巴细胞辐射敏感性高于T淋巴细胞；DNA ssb的修复能力与DNA合成可能存在一定的联系。

Abstract

The synthesis of DNA in T, B lymphocytes was investigated by the determination of ,3,H-TdR incorporation after Gamma-irradiation. The DNA ssb (single strand breaks) and repair in lymphocytes were measured by alkaline elution. The DNA synthesis in B lymphocytes was much lower than that in T lymphocytes. No significant difference in DNA ssb was found between T and B lymphocytes, but a less efficient process of repair was observed in B lymphocytes, So it was conceived that B lymphocytes were more sensitive to Gamma-irradiation than T lymphocytes and DNA synthesis might be related with the repair of DNA ssb.

关键词

DNA合成DNA ssbDNA修复T、B淋巴细胞辐射敏感性碱洗脱法

Keywords

DNA synthesisDNA ssbDNA repairT lymphocytesB lymphocytesRadiosensitivityAlkaline elution

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School of Radiation Medicine and Public Health of Soochow University

Changzhou Second Hospital

College of Radiation Medicine and Public Health of Soochow University

Institute of Radiation Medicine

Dept. of Radiation Medicine, 2nd Military Medical University

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COMPARISON STUDY OF DNA SYNTHESIS, SINGLE STRAND BREAKS AND REPAIR IN T AND B LYMPHOCYTES AFTER 60Co GAMMA-RAYS IRRADIATION

DOI：

摘要

Abstract

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COMPARISON STUDY OF DNA SYNTHESIS, SINGLE STRAND BREAKS AND REPAIR IN T AND B LYMPHOCYTES AFTER ⁶⁰Co GAMMA-RAYS IRRADIATION