STUDY ON RADIOGENOTOXICOLOGICAL EFFECT INDUCED BY RETENTION OF FISSION PRODUCO <sup>147</sup>Pm

Zhu Shoupeng; Zheng Siying; Luo Zhongyu; Wang Liuyi; Zhao Xinying

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STUDY ON RADIOGENOTOXICOLOGICAL EFFECT INDUCED BY RETENTION OF FISSION PRODUCO ¹⁴⁷Pm

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- STUDY ON RADIOGENOTOXICOLOGICAL EFFECT INDUCED BY RETENTION OF FISSION PRODUCO ¹⁴⁷Pm
- Journal of Radiation Research and Radiation Processing Vol. 6, Issue 3, Pages: 22-28(1988)
- 作者机构：
  
  1.苏州医学院，苏州
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Zhu Shoupeng, Zheng Siying, Luo Zhongyu, et al. STUDY ON RADIOGENOTOXICOLOGICAL EFFECT INDUCED BY RETENTION OF FISSION PRODUCO ¹⁴⁷Pm. [J]. Journal of Radiation Research and Radiation Processing 6(3):22-28(1988)
DOI：

Zhu Shoupeng, Zheng Siying, Luo Zhongyu, et al. STUDY ON RADIOGENOTOXICOLOGICAL EFFECT INDUCED BY RETENTION OF FISSION PRODUCO ¹⁴⁷Pm. [J]. Journal of Radiation Research and Radiation Processing 6(3):22-28(1988) DOI：

摘要

本研究观察了当机体摄入不同放射量裂变产物,147,Pm时的体内选择性蓄积部位骨髓细胞染色体畸变、姐妹染色单体互换（SCE）频率和微核率变化的诱发效应。实验结果表明，小剂量,147,Pm以诱发骨髓细胞染色单体型畸变为主。而随着,147,Pm摄入量的增加，可出现染色体断裂和易位。,147,Pm摄入量与骨髓细胞染色体畸变率之间呈半对数直线效应关系，拟合的对数回归方程式为：Y=10.69+1.435 lnX。同时骨髓畸变细胞与,147,Pm摄入量之间亦呈现线性关系，拟合的方程式为：Y=9.61+1.24 lnX,147,Pm内污染机体后，可诱发骨髓细胞SCE率和微核的阳性率明显升高，且随着,147,Pm摄入量的加大，微核阳性率亦进一步增升。

Abstract

The purpose of this study is to ascertain ,147,Pm retention in organism and its radiogenotoxicological effect induced by different doses. The dynamic retention of radioactivity in the body showed that iv different doses of ,147,Pm were all selectively and chiefly localized in liver and skeleton.,Studies indicated that the chromosome aberration rates were elevated when the radioactive doses of ,147,Pm were increased. It showed a linear relationship between radioactive doses and effect:,http://html.publish.founderss.cn/rc-pub/api/common/picture?pictureId=42649031&type=,http://html.publish.founderss.cn/rc-pub/api/common/picture?pictureId=42649063&type=,http://html.publish.founderss.cn/rc-pub/api/common/picture?pictureId=42649048&type=,Internal contamination of ,147,Pm can be induced 4 chromatid breakage in one cell. This phenomenon might be due in part to nonuniform irradiation of bone marrow cells with local deposition of ,147,Pm. In addition, among the types of aberrations induced by ,147,Pm were predominantly of chromatid type, accompanied with a few chromosome breakage and translocation.,The ability of ,147,Pm to induce SCEs has been investigated using IUdR labelling methods. A statistically significant elevation of SCEs was observed after ,147,Pm injection. The number of SCEs per cell in bone marrow cells were always higher in mice when the animals were maintained on the radioactive dose of 0.001 µCi/g level of ,147,Pm.,We observed the injurious effects of ,147,Pm, using micronucleus rates in bone marrow cells. The results showed that obvious increase of micronucleus rates could be induced by ,147,Pm wih low dose as 0.005 µCi/g. While the peak value appeared at 1.34% after injecting 5 µCi/g of ,147,Pm for 24 hr,In general, the induction of chromosomal alterations by ,147,Pm radiation is probably the most readily discernible early manifestation of radiation damage to proliferating cells. The threshold dose of ,147,Pm to induce chromosome aberration was only 0.001 µCi/g. This value was lower than ALI of ,147,Pm, as reported by ICRP publication.

关键词

裂变产物147Pm放射遗传毒理效应染色体畸变姐妹染色单体互换微核

Keywords

Fission product 147PmRetentionRadiogenotoxicological effectChromosome aberrationsSCEsMicronucleus

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STUDY ON RADIOGENOTOXICOLOGICAL EFFECT INDUCED BY RETENTION OF FISSION PRODUCO 147Pm

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STUDY ON RADIOGENOTOXICOLOGICAL EFFECT INDUCED BY RETENTION OF FISSION PRODUCO ¹⁴⁷Pm