INFLUENCES OF γ RAYS COMBIND WITH N-METHYL-N'-NITRO-N-NITROSOGUANIDINE(MNNG) ON THE BIOLOGICAL EFFECTS OF Hela CELLS

Cao Enhua; Wang Jujun; Xin Shumin

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INFLUENCES OF γ RAYS COMBIND WITH N-METHYL-N'-NITRO-N-NITROSOGUANIDINE(MNNG) ON THE BIOLOGICAL EFFECTS OF Hela CELLS

更新时间：2023-04-23

- INFLUENCES OF γ RAYS COMBIND WITH N-METHYL-N'-NITRO-N-NITROSOGUANIDINE(MNNG) ON THE BIOLOGICAL EFFECTS OF Hela CELLS
- Journal of Radiation Research and Radiation Processing Vol. 8, Issue 2, Pages: 86-89(1990)
- 作者机构：
  
  1.中国科学院生物物理研究所，北京
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Cao Enhua, Wang Jujun, Xin Shumin. INFLUENCES OF γ RAYS COMBIND WITH N-METHYL-N'-NITRO-N-NITROSOGUANIDINE(MNNG) ON THE BIOLOGICAL EFFECTS OF Hela CELLS. [J]. Journal of Radiation Research and Radiation Processing 8(2):86-89(1990)
DOI：

Cao Enhua, Wang Jujun, Xin Shumin. INFLUENCES OF γ RAYS COMBIND WITH N-METHYL-N'-NITRO-N-NITROSOGUANIDINE(MNNG) ON THE BIOLOGICAL EFFECTS OF Hela CELLS. [J]. Journal of Radiation Research and Radiation Processing 8(2):86-89(1990) DOI：

摘要

本文报道了γ线和N-甲基-N'-硝基-N-亚硝基胍（MNNG）对HeLa细胞存活率、DNA链断裂和O,6,-甲基鸟嘌呤DNA甲基转移酶活性的影响。结果表明两种因子的组合较单一因子增加了细胞的死亡率、DNA的链断裂及O,6,-甲基鸟嘌呤DNA甲基转移酶活性的丢失。细胞存活曲线参数D,0,， D,q,值的下降表明γ线与MNNG有协同作用。

Abstract

ABSTRACY By measuring the survivals of HeLa cells, DNA strand breaks and the activity of O,6,-methylguanine DNA methyltransferase, the biological effect of γ-rays and MNNG on HeLa cells was investigated. It was observed that the combined exposure of γ-rays and MNNG increased the cell lethality, DNA strand breaks and the inactivation of the O,6,-methylguanine DNA methyltransferase. The decrease of the survival curve parameters D,0, D,q, shown a synergism between γ-radiation and MNNG.

关键词

γ线N-甲基-N'-硝基-N-亚硝基胍DNA链断裂O6-甲基鸟嘌呤DNA甲基转移酶HeLa细胞

Keywords

γ-raysN-methyl-N'-nitro-N-nitrosoguanidineDNA strand breaksO6-methylguanine DNA methyltransferaseHeLa cells

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