RADIATION-CYTOGENETIC EFFECTS OF RADIOACTIVE NUCLIDES <sup>59</sup>F, <sup>60</sup>CO ON WISTAR RATS

Zhang Hongyuan; Wang Deheng; Taen Wuxun; Wen Quanfa; Cai Ping; Wang Lanjin; Zhao Shanyin; Hu yuexin; Li yong; Liu Tongshui

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RADIATION-CYTOGENETIC EFFECTS OF RADIOACTIVE NUCLIDES ⁵⁹F, ⁶⁰CO ON WISTAR RATS

更新时间：2023-04-23

- RADIATION-CYTOGENETIC EFFECTS OF RADIOACTIVE NUCLIDES ⁵⁹F, ⁶⁰CO ON WISTAR RATS
- Journal of Radiation Research and Radiation Processing Vol. 8, Issue 2, Pages: 95-99(1990)
- 作者机构：
  
  1.海军医学研究所，上海
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Zhang Hongyuan, Wang Deheng, Taen Wuxun, et al. RADIATION-CYTOGENETIC EFFECTS OF RADIOACTIVE NUCLIDES ⁵⁹F, ⁶⁰CO ON WISTAR RATS. [J]. Journal of Radiation Research and Radiation Processing 8(2):95-99(1990)
DOI：

Zhang Hongyuan, Wang Deheng, Taen Wuxun, et al. RADIATION-CYTOGENETIC EFFECTS OF RADIOACTIVE NUCLIDES ⁵⁹F, ⁶⁰CO ON WISTAR RATS. [J]. Journal of Radiation Research and Radiation Processing 8(2):95-99(1990) DOI：

摘要

59,Fe、,60,Co灌胃中毒幼年、成年、老年大鼠，每只一次平均中毒量（MBq）：,59,Fe分别为1.64、1.48、1.04；,60,Co分别为2.08、2.12、1.81。根据全身和脏器放射性测量结果得出的整体有效滞留分数方程估算大鼠全身和R. M累积剂量。结果表明：骨髓细胞和血淋巴细胞染色体畸变率均比对照组高，且绝大多数剂量点有统计学差异。两核素中毒老年大鼠骨髓细胞无着丝粒畸变率和R. M累积剂量呈线性相关；血淋巴细胞SCE的变化不明显。

Abstract

The radiactive nuclides were administered by gastric probe to rats with average activity 1.64, 1.48, 1.04, MBq/rat of ,59,Fe and 2.08, 2.12, 1.81 MBq/rat of ,60,Co respectively for young, adult and old groups. The cumulated internal doses to total body and R. M were calculated on the basis of radioactivity measurements on total body and organs. The results showed the chromosomal aberration yields of bone marrow cells and blood lymphocytes in experimental rats of various age-groups were higher than that of controls, the differences between the experimental and control groups were statistically significant at most dose points, moreover, the linear relationships existed between R. M cumulated doses and chromosome acentrics of bone marrow cells in old rats exposed to ,59,Fe and ,60,Co, the SCE incidences in lymphocytes of rats of various age-groups incorporated with ,59,Fe and ,60,Co did not greatly changed.

关键词

59Fe60Co放射细胞遗传效应染色体畸变姐妹染色单体互换

Keywords

59Fe60CoRadiation-Cytogenetic effectChromosomal aberrationSCE

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RADIATION-CYTOGENETIC EFFECTS OF RADIOACTIVE NUCLIDES 59F, 60CO ON WISTAR RATS

DOI：

摘要

Abstract

关键词

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RADIATION-CYTOGENETIC EFFECTS OF RADIOACTIVE NUCLIDES ⁵⁹F, ⁶⁰CO ON WISTAR RATS