EFFECT OF OXYGEN ON FORMATION OF MICRONUCLEI AND BINUCLEATE CELLS AND CELL SURVIVAL IN γ-IRRADIATED 3T3 CELLS

Zhang Peng; Zheng Xiulong

您当前的位置：

首页 >

文章列表页 >

EFFECT OF OXYGEN ON FORMATION OF MICRONUCLEI AND BINUCLEATE CELLS AND CELL SURVIVAL IN γ-IRRADIATED 3T3 CELLS

更新时间：2023-04-23

- EFFECT OF OXYGEN ON FORMATION OF MICRONUCLEI AND BINUCLEATE CELLS AND CELL SURVIVAL IN γ-IRRADIATED 3T3 CELLS
- Journal of Radiation Research and Radiation Processing Vol. 9, Issue 3, Pages: 145-149(1991)
- 作者机构：
  
  1.第二军医大学，上海
- 作者简介：
- 基金信息：
- DOI：
  CLC：
扫描看全文
Zhang Peng, Zheng Xiulong. EFFECT OF OXYGEN ON FORMATION OF MICRONUCLEI AND BINUCLEATE CELLS AND CELL SURVIVAL IN γ-IRRADIATED 3T3 CELLS. [J]. Journal of Radiation Research and Radiation Processing 9(3):145-149(1991)
DOI：

Zhang Peng, Zheng Xiulong. EFFECT OF OXYGEN ON FORMATION OF MICRONUCLEI AND BINUCLEATE CELLS AND CELL SURVIVAL IN γ-IRRADIATED 3T3 CELLS. [J]. Journal of Radiation Research and Radiation Processing 9(3):145-149(1991) DOI：

摘要

本文观察和比较了有氧及乏氧条件下，经,60,Coγ线照射后3T3细胞微核及双核细胞的形成及其与细胞存活率之间的关系。结果表明，在一定剂量范围内，有氧及乏氧照后，3T3细胞的微核率、微核细胞百分率及双核细胞百分率均与照射剂量呈线性关系。微核率、微核细胞百分率、双核细胞百分率及细胞存活率的氧增比分别为：2.02、1.96、1.87、及1.83。微核细胞百分率、双核细胞百分率及微核细胞与双核细胞之和的百分率均与细胞活存率之间有较好的相关性。本文还就3T3细胞辐射反应中的氧效应机制及微核及双核细胞形成的意义作了讨论。

Abstract

Formation of micronuclei and binucleate cells and their relationships with cell survival were studied in the aerobically- and anaerobically-irradiated 3T3 cells. The results showed that frequency of micronuclei, percentage of micronucleus cells and percentage of binucleate cells increased linearly with the radiation dose in certain range. Oxygen enhancement ratios (OER) of micronucleus frequency, percentage of micronucleus cells, percentage of binucleate cells and cell survival were 2.02,1.96, 1.87 and 1.83, respectively. The percentage of micronucleus cells or percentage of micronucleus cells plus binucleate cells correlated negatively well with cell survival. The mechanism of oxygen effect in the radiation response of 3T3 cells and the significance of formation of micronuclei and binucleate cells were discussed.

关键词

3T3细胞微核双核细胞氧效应

Keywords

3T3 cellsMicronucleiBinucleate cellsOxygen effect

references

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

The irradiation damage of mice induced by internal tritium oxide

Bystander effects of exposure to low-dose-rate ¹²⁵I seeds on human lung cancers cells in vitro

OXYGEN EFFECTS OF B₁₆ CELLS IRRADIATED BY 50Mev/u ¹²C⁶⁺

STUDY ON THE RADIATION DOSE EFFECT OF MICRO-NUCLEI DOSE USING CYTOKINESIS BLOCK METHOD

ENHANCEMENT OF RADIATION DAMAGE IN GERMINATING WHEAT SEEDS BY HYPERTHERMIA

Related Author

No data

Related Institution

School of Radiation Medicine and Public Health, Suzhou University

Jiangsu Provincial Key Laboratory of Radiation Medicine and Protection

Shanghai Institute of Applied Physics, Chinese Academy of Sciences

Institute of Radiation Medicine, Fudan University

Institute of Modern Physics, Chinese Academy of Sciences

⁰