GAMMA RADIATION EFFECT ON DNA REPAIR SYNTHESIS IN LYMPHOCYTES

Wei Kang; Liu Xueying; Zhou Pingkun; Sun Wenzhong

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GAMMA RADIATION EFFECT ON DNA REPAIR SYNTHESIS IN LYMPHOCYTES

更新时间：2023-04-23

- GAMMA RADIATION EFFECT ON DNA REPAIR SYNTHESIS IN LYMPHOCYTES
- Journal of Radiation Research and Radiation Processing Vol. 10, Issue 1, Pages: 20-24(1992)
- 作者机构：
  
  1.北京放射医学研究所，北京
- 作者简介：
- 基金信息：
  
  the International Atomic Energy Agency
- DOI：
  CLC：
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Wei Kang, Liu Xueying, Zhou Pingkun, et al. GAMMA RADIATION EFFECT ON DNA REPAIR SYNTHESIS IN LYMPHOCYTES. [J]. Journal of Radiation Research and Radiation Processing 10(1):20-24(1992)
DOI：

Wei Kang, Liu Xueying, Zhou Pingkun, et al. GAMMA RADIATION EFFECT ON DNA REPAIR SYNTHESIS IN LYMPHOCYTES. [J]. Journal of Radiation Research and Radiation Processing 10(1):20-24(1992) DOI：

摘要

本文用液体闪烁测量法和放射自显影法，测定小鼠及人淋巴细胞在紫外线诱发下的DNA周期外合成（UDS），发现小鼠经γ射线照射后3—4d，其淋巴结和血液的淋巴细胞在UV照射后的UDS明显下降，抑制程度随γ照射剂量增加而加重，二者呈线性依赖关系。两例中度放射病人的外周血淋巴细胞的UDS水平也低于正常。研究结果说明γ射线对细胞修复功能的影响值得重视，UDS测定也可作为辐射敏感指标使用。

Abstract

Unscheduled DNA synthesis in mouse and man lymphocytes was measured by liquid scintillation method and cell autoradiography after an ultraviolet exposure of 20 J/m,2, .The level of UDS was distinctly lowered in mouse lymph node and blood lymphocytes on the 3 rd—4 th day after γ-wholebody irradiation. The relationship between inhibitory effect and γ-radiation dose was linear. The average grain count per nucleus in blood lymphocytes of two patients, accidentally exposed to ,60,Co, was also reduced. The results demonstrate that the inhibition of DNA excision repair ability must be taken into account of radiation injury effect on cells. The estimation of UV induced UDS might be used as a radiosensitive biological indicator.

关键词

DNA周期外合成辐射损伤淋巴细胞DNA修复

Keywords

Unscheduled DNA synthesisRadiation injuryLymphocyteDNA repair

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