STUDIES ON DNA DSB AND ITS REJOINING REPAIR IN A MUTATED RADIOSENSITIVE MOUSE MAMMARY CANCER CELL LINE, SX-9

Zhou Pingkun; Wei Kang

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STUDIES ON DNA DSB AND ITS REJOINING REPAIR IN A MUTATED RADIOSENSITIVE MOUSE MAMMARY CANCER CELL LINE, SX-9

更新时间：2023-04-23

- STUDIES ON DNA DSB AND ITS REJOINING REPAIR IN A MUTATED RADIOSENSITIVE MOUSE MAMMARY CANCER CELL LINE, SX-9
- Journal of Radiation Research and Radiation Processing Vol. 10, Issue 1, Pages: 44-47(1992)
- 作者机构：
  
  1.军事医学科学院放射医学研究所，北京
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Zhou Pingkun, Wei Kang. STUDIES ON DNA DSB AND ITS REJOINING REPAIR IN A MUTATED RADIOSENSITIVE MOUSE MAMMARY CANCER CELL LINE, SX-9. [J]. Journal of Radiation Research and Radiation Processing 10(1):44-47(1992)
DOI：

Zhou Pingkun, Wei Kang. STUDIES ON DNA DSB AND ITS REJOINING REPAIR IN A MUTATED RADIOSENSITIVE MOUSE MAMMARY CANCER CELL LINE, SX-9. [J]. Journal of Radiation Research and Radiation Processing 10(1):44-47(1992) DOI：

摘要

本研究采用一种新的细胞DNA双链断裂检测方法——脉冲电场电泳法，检测了两株来源相同而辐射敏感性不同的细胞SR-1和SX-9的X线照射所致DNA双链断裂的产生和修复。结果表明两株细胞的DNA双链断裂产生没有差别，而辐射敏感细胞SX-9的DNA双链断裂重接修复能力明显低于SR-1细胞，本文对此结果与细胞辐射敏感性的关系进行了讨论。

Abstract

The intinial amount and repair of DNA double strand breaks (DSBs)in the radiosensitive cell SX-9 and wild-type cell SR-1 irradiated by X ray were detected by pulsed field gel electrophoresis. The results showed that the extent of DNA DSBs was similar in these two cell lines under same X ray doses, but the rejoining repairca pability of DNA DSBs in SX-9 cells was significantly lower than that in SR-1 cells. Results suggested that the increased radiosensitivity in SX-9 cells could be correlated with a defect in the repair of DNA DSBs.

关键词

DNA双链断裂细胞辐射敏感性脉冲电场电泳辐射敏感突变株

Keywords

DNA double strand breaks (DSBs)RadiosensitivityPulsed field gel electrophoresisRadiosensitive mutant

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