THE STUDY ON DOSE-RESPONSE RELATIONSHIP OF MICRONUCLEI IN HUMAN LYMPHOCYTES INDUCED BY LOW DOSE RADIATION

Wang Zhiquan; Tang Weisheng; Chen Zhenjun; Wang Yushu

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THE STUDY ON DOSE-RESPONSE RELATIONSHIP OF MICRONUCLEI IN HUMAN LYMPHOCYTES INDUCED BY LOW DOSE RADIATION

更新时间：2023-04-23

- THE STUDY ON DOSE-RESPONSE RELATIONSHIP OF MICRONUCLEI IN HUMAN LYMPHOCYTES INDUCED BY LOW DOSE RADIATION
- Journal of Radiation Research and Radiation Processing Vol. 11, Issue 1, Pages: 7-10(1993)
- 作者机构：
  
  1.中国医学科学院放射医学研究所，天津　300192
- 作者简介：
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Wang Zhiquan, Tang Weisheng, Chen Zhenjun, et al. THE STUDY ON DOSE-RESPONSE RELATIONSHIP OF MICRONUCLEI IN HUMAN LYMPHOCYTES INDUCED BY LOW DOSE RADIATION. [J]. Journal of Radiation Research and Radiation Processing 11(1):7-10(1993)
DOI：

Wang Zhiquan, Tang Weisheng, Chen Zhenjun, et al. THE STUDY ON DOSE-RESPONSE RELATIONSHIP OF MICRONUCLEI IN HUMAN LYMPHOCYTES INDUCED BY LOW DOSE RADIATION. [J]. Journal of Radiation Research and Radiation Processing 11(1):7-10(1993) DOI：

摘要

用50 h、72 h常规培养法和胞质分裂阻断微核（CBMN）法，比较低剂量照射人离体血淋巴细胞所诱发的微核率和微核细胞率。结果表明，微核率和微核细胞率均随着剂量增加而增加；50 h培养和CBMN的剂量效应关系呈直线模式，而72 h培养则呈纯二次式；CBMN比常规培养（50 h和72 h培养）更为灵敏和准确，离体照射0.1 Gy微核率和微核细胞率就可明显检出。

Abstract

Comparative studies on frequencies of micronucleus (MN) and cells with MN from human blood lymphocytes in vitro which exposed to low dose radiation were carried out using conventional methods for culture time 50 h and 72 b and cytokinesis-block micronucleus method (CBMN). The experiment results showed that the frequencies of MN and cells with MN increased with dose. Dose-response relationship for conventional method of culture time 50 h and CBMN method were linear model, while culture time 72 h was quadratic ones; CBMN method is more sensitive and precise than conventional 2 methods; The frequencies of MN and cells with MN could be unequivocally detected if the blood was exposed to 0.1 Gy of ,137,Cs γ-rays in vitro.

关键词

低剂量辐射人体淋巴细胞CB微核剂量效应关系

Keywords

Low dose radiationHuman lymphocytesCBMNDose-response relationship

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