ACCMULATIVE EFFECT OF TWO LOW DOSES OF IRRADIATION IN INDUCING AN ADAPTIVE RESPONSE IN HUMAN LYMPHOCYTES

Bai Yongli; Chen Deqing

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ACCMULATIVE EFFECT OF TWO LOW DOSES OF IRRADIATION IN INDUCING AN ADAPTIVE RESPONSE IN HUMAN LYMPHOCYTES

更新时间：2023-04-23

- ACCMULATIVE EFFECT OF TWO LOW DOSES OF IRRADIATION IN INDUCING AN ADAPTIVE RESPONSE IN HUMAN LYMPHOCYTES
- Journal of Radiation Research and Radiation Processing Vol. 12, Issue 1, Pages: 34-39(1994)
- 作者机构：
  
  1.卫生部工业卫生实验所，北京　100088
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Bai Yongli, Chen Deqing. ACCMULATIVE EFFECT OF TWO LOW DOSES OF IRRADIATION IN INDUCING AN ADAPTIVE RESPONSE IN HUMAN LYMPHOCYTES. [J]. Journal of Radiation Research and Radiation Processing 12(1):34-39(1994)
DOI：

Bai Yongli, Chen Deqing. ACCMULATIVE EFFECT OF TWO LOW DOSES OF IRRADIATION IN INDUCING AN ADAPTIVE RESPONSE IN HUMAN LYMPHOCYTES. [J]. Journal of Radiation Research and Radiation Processing 12(1):34-39(1994) DOI：

摘要

人外周血淋巴细胞在离体培养后6 h时，预先受到小剂量1、2、5、10或20 cGy ,60,Co γ射线单次照射，能降低随后100 cGy照射所引起的染色单体畸变，而0.5或30 cGy则不明显。1.0 cGy诱导的适应性反应最明显，是诱导适应性反应的最适剂量（饱和剂量）。淋巴细胞分别在培养后6 h和12h、6 h和42 h或36 h和42 h时，预先受到0.5 cGy ,60,Co γ射线两次照射，均能显著降低在培养后48 h受到大剂量150 cGy ,60,Co ,γ,射线照射所诱发的染色单体畸变，且0.5 cGy两次与1.0 cGy单次照射所产生的作用相似，这显示0.5 cGy两次照射能引起累加作用，而且在培养后36 h和42 h 0.5 cGy照射两次出现超常适应性反应。在上述时间内1.0 cGy γ射线两次照射，其结果与1.0 cGy单次照射的结果几乎相同，这进一步表明1.0 cGy已达适应性反应的饱和剂量。

Abstract

A chromosomal adaptive response to ,60,Co γ-rays in human lymphocytes was observed with pretreated doses ranged from 1.0 to 20 cGy, with 1.0 cGy gave optimal reduction in chromatid breaks. A 0.5 cGy dose which in itself did not induce an adaptive response, did so when given twice within the same cell cycle, and the magnitude of accumulative effect is the strongest when there was an interval of 6 h between the two adaptive doses and between the second adaptive dose and a challenge dose. Reductions equivalent in effect to a single 1.0 cGy dose were seen when a 0.5 cGy dose was given twice. Delivering two 1.0 cGy doses had no greater effect than did a single dose of 1.0 cGy.

关键词

适应性反应单次适应剂量两次适应剂量人淋巴细胞γ辐射

Keywords

Adaptive responseChromatid breaksAdaptive dose(s)Human lymphocytesγ-radiation

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