STUDIES OF ANTIBODY SECRETING FUNCTIONS OF B LYMPHOCYTE HYBRIDOMA CELLS AFTER γ-IRRADIATION

Chen Chuansong; Xu Jianren

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STUDIES OF ANTIBODY SECRETING FUNCTIONS OF B LYMPHOCYTE HYBRIDOMA CELLS AFTER γ-IRRADIATION

更新时间：2023-04-23

- STUDIES OF ANTIBODY SECRETING FUNCTIONS OF B LYMPHOCYTE HYBRIDOMA CELLS AFTER γ-IRRADIATION
- Journal of Radiation Research and Radiation Processing Vol. 12, Issue 2, Pages: 87-90(1994)
- 作者机构：
  
  1.第二军医大学放射医学研究室，上海　200433
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Chen Chuansong, Xu Jianren. STUDIES OF ANTIBODY SECRETING FUNCTIONS OF B LYMPHOCYTE HYBRIDOMA CELLS AFTER γ-IRRADIATION. [J]. Journal of Radiation Research and Radiation Processing 12(2):87-90(1994)
DOI：

Chen Chuansong, Xu Jianren. STUDIES OF ANTIBODY SECRETING FUNCTIONS OF B LYMPHOCYTE HYBRIDOMA CELLS AFTER γ-IRRADIATION. [J]. Journal of Radiation Research and Radiation Processing 12(2):87-90(1994) DOI：

摘要

分泌特异性抗体的B淋巴杂交瘤细胞，是高度分化的免疫活性细胞。在,60,Co γ射线作用下，抗体分泌总量随受照剂量的增大而降低。然而每个克隆细胞的抗体分泌量却随受照射剂量的增加而有上升趋势。抗体分泌细胞受照射后抗体分泌浓度增加的效应，经细胞传代、冻存后丧失。表明抗体分泌功能的增强，是由于电离辐射一过性刺激的结果。实验表明，高度分化了的抗体分泌细胞在电离辐射作用下，存在着潜在致死性损伤，但这种损伤不影响存活细胞的抗体分泌功能。因而提示在放射损伤治疗中，使用能促进免疫细胞分裂、增殖的因子或药物，可能有利于机体免疫功能的恢复。

Abstract

The antibody secreting B lymphocyte hybridoma cells were irradiated with ,60,Co γ-rays. A markedly dose-related depression of total production of specific antibody was observed. However, production of specific antibody per clone was raised with increase of radiation dose. The increase in antibody secretion by B lymphocyte hybridoma cells was lost after long term culture and freezing of survival cells. γ-radiation could induce potentially lethal damage of monoclonal antibody secreting cells, but this damage didn't affect the antibody secreting function of those surviving cells. These results indicate that ionizing radiation stimulates the secreting function of B lymphocyte hybridoma cells in the initial period after exposure.

关键词

γ辐射抗体分泌细胞杂交瘤细胞辐射效应

Keywords

γ-radiationAntibody secreting cellHybridomaRadiation effect

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