THE NUCLEIC ACID PRECURSORS CAN ENHANCE THE INTESTINAL CRYPT SURVIVAL IN MICE AFTER 980 cGy ABDOMINAL γ-IRRADIATION

Zhou Yuankai; Liu Aiping; Zeng Guiying

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THE NUCLEIC ACID PRECURSORS CAN ENHANCE THE INTESTINAL CRYPT SURVIVAL IN MICE AFTER 980 cGy ABDOMINAL γ-IRRADIATION

更新时间：2023-04-23

- THE NUCLEIC ACID PRECURSORS CAN ENHANCE THE INTESTINAL CRYPT SURVIVAL IN MICE AFTER 980 cGy ABDOMINAL γ-IRRADIATION
- Journal of Radiation Research and Radiation Processing Vol. 12, Issue 2, Pages: 96-99(1994)
- 作者机构：
  
  1.第四军医大学防原医学教研室，西安　710032
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Zhou Yuankai, Liu Aiping, Zeng Guiying. THE NUCLEIC ACID PRECURSORS CAN ENHANCE THE INTESTINAL CRYPT SURVIVAL IN MICE AFTER 980 cGy ABDOMINAL γ-IRRADIATION. [J]. Journal of Radiation Research and Radiation Processing 12(2):96-99(1994)
DOI：

Zhou Yuankai, Liu Aiping, Zeng Guiying. THE NUCLEIC ACID PRECURSORS CAN ENHANCE THE INTESTINAL CRYPT SURVIVAL IN MICE AFTER 980 cGy ABDOMINAL γ-IRRADIATION. [J]. Journal of Radiation Research and Radiation Processing 12(2):96-99(1994) DOI：

摘要

小鼠经980cGy γ射线腹部照射后，用局部肠腔扩张注入法，将被测试剂注入空肠肠腔内。于照射后第4 d活杀小鼠，测定注入肠段和对照肠段的肠腺存活率。结果表明：单独一种嘌呤类或嘧啶类核苷酸、核苷和碱基，同小牛胸腺DNA一样，具有提高照射后肠腺存活率的作用。这一事实提示，外源核酸对辐射损伤细胞或机体的恢复效应，并非由于其高聚状态，而是其酶解产物作用所致。

Abstract

The effect of a single post-irradiation intestinal lumen dilatation injection of one of mononucleotides, nucleosides or nucleic acid bases on intestinal crypt survival after 980 cGy abdominally γ-irradiated mice has been studied. The results showed that, any one of these nucleic acid components can produce the same enhancing effect of crypt survival as that did by polymerized calf thymus DNA. This fact suggests that, the radiorestorative effect of exogenous nucleic acids on the intestinal crypt cells depends not upon the action exerted by their highly polymerised state, but rather by their various enzymatic degradation products.

关键词

电离辐射核酸组分肠腺存活率

Keywords

Ionizing radiationNucleic acid componentIntestinal crypt survival

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