STUDY ON THE TRANSFERENCE AND RETENTION OF <sup>75</sup>Se-METHIONINE IN WHOLE BODY, ORGANS AND CELLS

Zhu Shoupeng; Chu Xianxiang; Wang Guolin

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STUDY ON THE TRANSFERENCE AND RETENTION OF ⁷⁵Se-METHIONINE IN WHOLE BODY, ORGANS AND CELLS

更新时间：2023-04-23

- STUDY ON THE TRANSFERENCE AND RETENTION OF ⁷⁵Se-METHIONINE IN WHOLE BODY, ORGANS AND CELLS
- Journal of Radiation Research and Radiation Processing Vol. 12, Issue 3, Pages: 179-185(1994)
- 作者机构：
  
  1.苏州医学院放射医学系，苏州　215007
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Zhu Shoupeng, Chu Xianxiang, Wang Guolin. STUDY ON THE TRANSFERENCE AND RETENTION OF ⁷⁵Se-METHIONINE IN WHOLE BODY, ORGANS AND CELLS. [J]. Journal of Radiation Research and Radiation Processing 12(3):179-185(1994)
DOI：

Zhu Shoupeng, Chu Xianxiang, Wang Guolin. STUDY ON THE TRANSFERENCE AND RETENTION OF ⁷⁵Se-METHIONINE IN WHOLE BODY, ORGANS AND CELLS. [J]. Journal of Radiation Research and Radiation Processing 12(3):179-185(1994) DOI：

摘要

研究了,75,Se-蛋氨酸注入机体内在全身、脏器和细胞水平的转运和滞留过程：设计用整体测量装置测得的全身滞留方程为R(t)=24.06e,-0.679t,+41.24e,-0.042t,＋15.41 e,-0.005t,。可见有速度不同的三个半滞留期T,1,=1.0 d、T,2,=16.4 d、T,3,=132 d，而在尿和粪中的排除都有快和慢两个组分，尿的T,1, =0.6 d, T,2,=9.8 d；粪的T,1,=5.2 d，T,2,=13.2 d。进而运用脏器水平放射自显影和细胞水平放射自显影及荧光增敏放射自显影研究了,75,Se-蛋氨酸注入后在脏器和细胞水平的转运和滞留特性，观察到其蓄积依次为胰腺、肝脏、甲状腺、骨骼和骨髓，而在毛发中仅见痕量。从而提供了,75,Se-蛋氨酸在体内不同水平的滞留和作用依据。

Abstract

The dynamic of the whole body retention in rats after iv ,75,Semethionine was determined by whole body counting. The retantion was well described by a three-component equation: R (t)=24.06 e,-0.679t,+41.24 e,-0.042t,+15.41 e,-0.005t, wherein the t,1/2, were T,1,=1.0 d, T,2,=16.4d,T,3,=132 d. The radioactivities in urine revealed 2 components with t,1/2,=0.6 and 9.8 d respectively. Biological t,1/2,=5.2 d in fecal excretion for the fast component and 13.2 d for the long term component. The autoradiographic study indicated that after iv ,75,Se-methionine in rats the radioactivity accumulated chiefly in pancreas, and then in liver, skeleton and thyroid gland, only a trace was found in hair. A method was studied for rapid preparation of autoradiographs for tissue slices by impregnation of nuclear emulsion with liquid scintillators PPO and POPOP. Mixing liquid scintillators, especially a hydrophilic dioxane solvent, with emulsion allowed also rapid autoradiographic grain production. The tissue distribution of ,75,Se-methionine by fluorescence-sensitized autoradiography was observed after iv ,75,Se-methionine. The number of autoradiographic grains/10 µm,2, was increased with the scintillator by 4—10 times. The silver grains in the autoradiograms were distributed high in the pancreatic acini and the islets, and then in liver cells, bone marrow and epithelial cells of thyroid gland.

关键词

放射示踪75Se-蛋氨酸全身水平脏器水平细胞水平滞留

Keywords

Radioactive tracing75Se-methionineWhole body levelOrgan levelCell levelRetention

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Department of Medical Radiobiology, Suzhou Medical College

Institute of Naval Medical Research

Suzhou Medical College

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STUDY ON THE TRANSFERENCE AND RETENTION OF 75Se-METHIONINE IN WHOLE BODY, ORGANS AND CELLS

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STUDY ON THE TRANSFERENCE AND RETENTION OF ⁷⁵Se-METHIONINE IN WHOLE BODY, ORGANS AND CELLS