THE EFFECTS OF RADIATION ON ACTIVITY AND NUMBER OF NK CELL

Min Rui; Cheng Tianmin; Luo Chengji; Chen Qi; Din Zhenhai; Mon Xiangshun

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THE EFFECTS OF RADIATION ON ACTIVITY AND NUMBER OF NK CELL

更新时间：2023-04-23

- THE EFFECTS OF RADIATION ON ACTIVITY AND NUMBER OF NK CELL
- Journal of Radiation Research and Radiation Processing Vol. 12, Issue 3, Pages: 189-192(1994)
- 作者机构：
  
  1.第二军医大学放射医学研究室，上海　200433
  1.第三军医大学防原医学教研室，重庆　630038
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Min Rui, Cheng Tianmin, Luo Chengji, et al. THE EFFECTS OF RADIATION ON ACTIVITY AND NUMBER OF NK CELL. [J]. Journal of Radiation Research and Radiation Processing 12(3):189-192(1994)
DOI：

Min Rui, Cheng Tianmin, Luo Chengji, et al. THE EFFECTS OF RADIATION ON ACTIVITY AND NUMBER OF NK CELL. [J]. Journal of Radiation Research and Radiation Processing 12(3):189-192(1994) DOI：

摘要

正常人外周血单个核细胞（PBMCs）体外经1—6 Gy γ射线照射，照射后不同时间，H,3,-TdR释放法测NK细胞活性，免疫细胞化学法计数CD,57,阳性NK细胞数。发现在2 Gy照射剂量范围NK活性基本不变，增大照射剂量活性逐渐下降。NK细胞活性亦随照射后时间而变化，照射后12 h活性最低，随后逐渐恢复，恢复程度与受照射剂量有关。实验照射剂量范围，NK细胞数量改变不明显。rIL-2刺激受照NK细胞可显著增强活力。

Abstract

Peripheral blood mononuclear cells from normal persons were irradiated by 1—6 Gy γ-rays in vitro. NK activity was determined by means of ,3,H-TdR releasing and CD,57, positive cells were counted by means of immunocytochemistry, respectively. The results showed that NK cell activity changed unobviously whthin 2 Gy irradiation dose and dropped gradually with increasing irradiation dose and was distinguished lower than that of control when irradiation dose increased to 6 Gy. NK cell activity changed with time and was lowest at 12 hours after irradiation, then it restored gradually. The restoring level of NK cell activity was related to irradiation dose. The number of NK cell had little change till 6 Gy irradiation. The activity of NK cell increased significantly when irradiated cells were stimulated with IL-2.

关键词

电离辐射NK细胞免疫细胞化学

Keywords

IrradiationNK cellImmunocytochemistry

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