EFFECTS ON REGULATION BETWEEN LYMPHOCYTE SUBSETS AFTER LOW DOSE RADIATION

Du Zeji; Su Liaoyuan; Liu Fenju

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EFFECTS ON REGULATION BETWEEN LYMPHOCYTE SUBSETS AFTER LOW DOSE RADIATION

更新时间：2023-04-23

- EFFECTS ON REGULATION BETWEEN LYMPHOCYTE SUBSETS AFTER LOW DOSE RADIATION
- Journal of Radiation Research and Radiation Processing Vol. 12, Issue 4, Pages: 247-250(1994)
- 作者机构：
  
  1.苏州医学院放射医学系　苏州　215007
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Du Zeji, Su Liaoyuan, Liu Fenju. EFFECTS ON REGULATION BETWEEN LYMPHOCYTE SUBSETS AFTER LOW DOSE RADIATION. [J]. Journal of Radiation Research and Radiation Processing 12(4):247-250(1994)
DOI：

Du Zeji, Su Liaoyuan, Liu Fenju. EFFECTS ON REGULATION BETWEEN LYMPHOCYTE SUBSETS AFTER LOW DOSE RADIATION. [J]. Journal of Radiation Research and Radiation Processing 12(4):247-250(1994) DOI：

摘要

应用单克隆抗体铺皿法分离出CD4,+,、CD8,+,和B细胞，小剂量X射线照射前两种细胞，观察照后的CD4,+,、CD8,+,对B细胞,3,H-TdR参入的影响。结果表明，正常CD4,+,细胞对B细胞具有辅助作用，CD4,+,细胞对B细胞具有抑制作用，小剂量照射可加强CD4,+,对B细胞的辅助作用，促进CD8,+,对B细胞的抑制作用，以0.10 Gy照射后这种效应最强，0.20 Gy照射后仍可观察到这种效应。

Abstract

Monoclonal antibodies of anti CD4, anti CD8 and anti B wereused to separate CD4,+, CD8,+, and B lymphocyte subsets respectively. After low dose X-rays radiation, the regulatory functions of CD4,+, and CD8,+, on B cell were studied by using ,3,H-TdR incorporation. The results indicated that CD4,+, cell could increase the ,3,H-TdR incorporation of B cell, CD8,+, could decrease the ,3,H-TdR incorporation of B cell. Low dose radiation could enhance the helping effect of CD4,+, and inhibitive effect of CD8,+, on B cell at a dose range of 0.02—0.20 Gy, especially at the dose of 0.10 Gy X-rays radiation.

关键词

小剂量辐射淋巴细胞亚群相互作用生物辐射效应

Keywords

Low dose radiationLymphocyte subsetsInter-regulationBiologi cal radiation effects

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