EFFECT OF 5-HT ON IMMUNE FUNCTIONS OF MOUSE SPLENOCYTES IRRADIATED WITH LOW DOSES

Zhao Yong; Gong Shouliang; Liu Shuzheng

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EFFECT OF 5-HT ON IMMUNE FUNCTIONS OF MOUSE SPLENOCYTES IRRADIATED WITH LOW DOSES

更新时间：2023-04-23

- EFFECT OF 5-HT ON IMMUNE FUNCTIONS OF MOUSE SPLENOCYTES IRRADIATED WITH LOW DOSES
- Journal of Radiation Research and Radiation Processing Vol. 13, Issue 3, Pages: 173-176(1995)
- 作者机构：
  
  1.白求恩医科大学放射生物教研室，长春　130021
- 作者简介：
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Zhao Yong, Gong Shouliang, Liu Shuzheng. EFFECT OF 5-HT ON IMMUNE FUNCTIONS OF MOUSE SPLENOCYTES IRRADIATED WITH LOW DOSES. [J]. Journal of Radiation Research and Radiation Processing 13(3):173-176(1995)
DOI：

Zhao Yong, Gong Shouliang, Liu Shuzheng. EFFECT OF 5-HT ON IMMUNE FUNCTIONS OF MOUSE SPLENOCYTES IRRADIATED WITH LOW DOSES. [J]. Journal of Radiation Research and Radiation Processing 13(3):173-176(1995) DOI：

摘要

应用培养雄性昆明系小鼠脾细胞技术，观察5-HT对75 mGyX射线体内和体外照射脾细胞免疫功能的影响。结果发现，5-HT明显抑制正常脾细胞自发增殖能力，但对正常脾细胞ConA反应性影响不明显；当5-HT在一定浓度时，75 mGy体内和体外照射的脾细胞对ConA反应性均增强。提示，5-HT可抑制正常脾细胞免疫功能，并在一定程度上参与小剂量辐射的免疫刺激作用；但一定浓度5-HT对体内和体外照射脾细胞增殖能力的影响不同，体内照射时增强，体外照射时抑制，推测与体内脾细胞微环境改变有关。

Abstract

The present study was designed to observe the effects of 5-HT on the immune functions of the splenocytes irradiated with 75 mGy X-rays in Kunmin male mice in vivo and in vitro. The results showed that 5-HT inhibited significantly the spotaneous proliferation of the normal splenocytes, but the effects of 5-HT on the responses of the normal splenocytes to ConA were not obvious. The responses of the splenocytes to ConA after X-irradiation with 75 mGy both in vivo and in vitro enhanced in certain concentration of 5-HT. The results suggest that 5-HT in certain amount may inhibit the splenocyte immune functions and participate in the immunoenhancement effect following low dose irradiation. But the effects of certain 5-TH concentrations on the proliferation of the splenocytes irradiated in vivo and in vitro were different. It increased in vivo, but inhibited in vitro. It is supposed that it may be related to the changes of the internal environment of the splenocytes.

关键词

X射线小剂量辐射5-羟色胺免疫调节

Keywords

X-raysLow dose irradiationSerotoninImmune regulation

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