EFFECTS OF LOW DOSE IRRADIATION ON THE SPLENIC MACROPHAGES FUNCTION IN MICE

Chen Zhiyun; Zhang Ming; Liu Shuzheng

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EFFECTS OF LOW DOSE IRRADIATION ON THE SPLENIC MACROPHAGES FUNCTION IN MICE

更新时间：2023-04-23

- EFFECTS OF LOW DOSE IRRADIATION ON THE SPLENIC MACROPHAGES FUNCTION IN MICE
- Journal of Radiation Research and Radiation Processing Vol. 13, Issue 3, Pages: 186-189,192(1995)
- 作者机构：
  
  1.白求恩医科大学放射生物教研室，长春　130021
- 作者简介：
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Chen Zhiyun, Zhang Ming, Liu Shuzheng. EFFECTS OF LOW DOSE IRRADIATION ON THE SPLENIC MACROPHAGES FUNCTION IN MICE. [J]. Journal of Radiation Research and Radiation Processing 13(3):186-189,192(1995)
DOI：

Chen Zhiyun, Zhang Ming, Liu Shuzheng. EFFECTS OF LOW DOSE IRRADIATION ON THE SPLENIC MACROPHAGES FUNCTION IN MICE. [J]. Journal of Radiation Research and Radiation Processing 13(3):186-189,192(1995) DOI：

摘要

采用昆明小鼠，小剂量X射线全身照射50 mGy～250 mGy，剂量率为12.5 mGy/min。停照后不同时间处死动物，取出脾脏，用贴壁法分离脾巨噬细胞（M,ϕ,）和淋巴细胞，检测受照后脾M,ϕ,与受照的脾淋巴细胞功能变化的关系。结果表明，小剂量辐射可使脾M,ϕ,功能增强，主要表现在75 mGy X射线全身照射后，脾M,ϕ,对脾淋巴细胞ConA（刀豆蛋白A）反应增强，IL-1（白细胞介素1）分泌增多。受照的脾M,ϕ,只对受照的脾淋巴细胞增强其ConA反应，而对未受照的脾淋巴细胞无显著影响；未受照的脾M,ϕ,也不能增强受照的脾淋巴细胞功能。

Abstract

It is known that low dose ionizing radiation stimulated the immune functions in human subjects and mice. In order to examine the situation of macrophages a series of changes in the immune system in Kunming mice following low dose whole body irradiation were observed based on the study of macrophages from spleen. The present study was designed by whole body X-rays with the doses of 50, 75, 100 and 250 mGy, respectively, The dose rate was 12.5 mGy/min. All the results showed that low dose irradiation may enhance the function of macrophages on the reaction of lymphocytes to ConA, and increase content of IL-1 from macrophages.

关键词

小剂量辐射脾巨噬细胞IL-1脾淋巴细胞

Keywords

Low dose irradiationSplenic macrophagesIL-1Splenic lymphocytes

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