EFFECTS OF Ach ON PROLIFERATIVE REACTION OF MURINE SPLENOCYTES RADIATED WITH LOW DOSE RADIATION

Zhao Yong; Gong Shouliang; Liu Shuzheng

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EFFECTS OF Ach ON PROLIFERATIVE REACTION OF MURINE SPLENOCYTES RADIATED WITH LOW DOSE RADIATION

更新时间：2023-04-23

- EFFECTS OF Ach ON PROLIFERATIVE REACTION OF MURINE SPLENOCYTES RADIATED WITH LOW DOSE RADIATION
- Journal of Radiation Research and Radiation Processing Vol. 14, Issue 4, Pages: 231-234(1996)
- 作者机构：
  
  1.白求恩医科大学放射生物教研室　长春　130021
- 作者简介：
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Zhao Yong, Gong Shouliang, Liu Shuzheng. EFFECTS OF Ach ON PROLIFERATIVE REACTION OF MURINE SPLENOCYTES RADIATED WITH LOW DOSE RADIATION. [J]. Journal of Radiation Research and Radiation Processing 14(4):231-234(1996)
DOI：

Zhao Yong, Gong Shouliang, Liu Shuzheng. EFFECTS OF Ach ON PROLIFERATIVE REACTION OF MURINE SPLENOCYTES RADIATED WITH LOW DOSE RADIATION. [J]. Journal of Radiation Research and Radiation Processing 14(4):231-234(1996) DOI：

摘要

采用75 mGy X射线全身和离体照射昆明系雄性小鼠脾细胞，观察乙酰胆碱（Ach）对其增殖反应的影响。其结果发现，Ach增强脾细胞自发增殖能力及对ConA反应性；75 mGy X射线全身和离体照射后脾细胞增殖反应变化不同，全身照射后早期增殖更为显著，而离体照射时似较未受照射细胞为差。提示，Ach可刺激脾细胞增殖反应，并在一定程度上具有小剂量辐射早期的刺激作用，但其在全身和离体照射对脾细胞增殖反应不同，推测与脾细胞微环境不同有关。

Abstract

The present study was designed to observe the effects of acetylcholine (Ach) on the proliferative reaction of the splenocytes irradiated with low dose X-rays in Kunmin male mice in vivo and in vitro. The results showed that Ach enhanced significantly the spontaneous proliferations of the splenocytes and the responses of the splenocytes to ConA. But, the immune functional changes of the splenocytes irradiated with 75 mGy in vivo and in vitro were different. It would increase more in vivo, while less in vitro. These results suggest that Ach may stimulate the splenocyte proliferative reaction and participate in the immunoenhanced effect following low dose radiation to a certain extent. However, the action mechanism of Ach on the immune functional changes of the splenocytes irradiated with low dose X-rays in vivo and in vitro may be different. It is supposed to have relation to the change of the microenvironment of the splenocytes.

关键词

X辐射小剂量辐射乙酰胆碱增殖反应

Keywords

X-radiationLow dose radiationAcetylcholineProliferative reaction

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